Differential modulations of lauric acid and its glycerides on high fat diet-induced metabolic disorders and gut microbiota dysbiosis.

Animals Diet, High-Fat / adverse effects Dysbiosis / metabolism Gastrointestinal Microbiome Glycerides Metabolic Diseases Mice
Glycerol monolaurate Gut microbiota Lauric acid Lauric triglyceride Metabolic disorders Serum lipidomic

Journal

Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143

Informations de publication

Date de publication:
07 2022
Historique:
received: 16 03 2022
revised: 24 05 2022
accepted: 25 05 2022
entrez: 28 6 2022
pubmed: 29 6 2022
medline: 30 6 2022
Statut: ppublish

Résumé

The anti-bacterial properties of lauric acid (LA) and its glycerides had been studied. However, their effects on gut microbiota remain unclear. Moreover, LA and its glycerides performed controversial influences on lipid metabolism. This study evaluated the regulation of LA, glycerol monolaurate (GML) and lauric triglyceride (GTL) on metabolic health and gut microbiota in high fat diet-fed mice. Serum metabolomics and lipidomics contributed to elucidate the underlying mechanisms. LA and its glycerides ameliorated hyperlipidemia, while GML performed more pronounced modulation on glucose metabolism and inflammation. LA and its glycerides modulated gut microbiota with increased Bifidobacterium and decreased Desulfovibrio, which closely related with metabolic improvements. Furthermore, the integrative multi-omics analyses identified that the regulation of phospholipid metabolism, intestinal microbial metabolites (bile acids and indole derivatives) and endogenous unsaturated fatty acids synthesis conduced to the more evident modulation of GML. Our findings suggested an effective strategy of GML for improving metabolism and gut health.

Identifiants

DOI: 10.1016/j.foodres.2022.111437 PMID: 35761677
pubmed: 35761677
pii: S0963-9969(22)00494-X
doi: 10.1016/j.foodres.2022.111437
pii:
doi:

Substances chimiques

Glycerides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111437

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Minjie Zhao (M)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China; ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China.

Junhui Zhang (J)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China.

Tao Liu (T)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China; ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China.

Jing Wang (J)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China; ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China.

Haiying Cai (H)

School of Biological & Chemical Engineering, Zhejiang Key Lab for Chem & Bio Processing Technology of Farm Product, Zhejiang University of Science and Technology, Hangzhou 310023, China.

Xi Zhang (X)

School of Chinese Materia Medica, Yunnan Universtiy of Chinese Medicine, Kunming 650500, China.

Doris Quay Huai Xia (D)

Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor Darul Ehsan 43600, Malaysia.

Fengqin Feng (F)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China; ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China. Electronic address: fengfq@zju.edu.cn.

Jun Tang (J)

College of Biosystems Engineering and Food Science, Ningbo Research Institute, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Zhejiang 310058, China; School of Life Sciences, Westlake University, Hangzhou 310024, China. Electronic address: tangjun59@westlake.edu.cn.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential modulations of lauric acid and...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Differential modulations of lauric acid and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Differential modulations of lauric acid and...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Differential modulations of lauric acid and...
questionsmedicales.fr › Lipides › Glycérides › Differential modulations of lauric acid and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Differential modulations of lauric acid and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential modulations of lauric acid and...