Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma.
PYGB
PYGL
PYGM
glycogen phosphorylase
hepatocellular carcinoma
Journal
Oncology letters
ISSN: 1792-1082
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
09
03
2022
accepted:
11
05
2022
entrez:
28
6
2022
pubmed:
29
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
Glycogen phosphorylase (GP) is an essential enzyme for glycolysis via the glycogen degradation pathway. It consists of three isoforms: PYGB (brain form), PYGL (liver form) and PYGM (muscle form). Although the abnormal expression of GP is associated with a variety of tumors, its relationship with hepatocellular carcinoma (HCC) and whether it can be used as a prognostic marker of HCC remains unclear. In the present study, the expression levels of PYGB, PYGL and PYGM were analyzed. It was found that the expression levels of PYGB in tumor tissues were higher than those in normal tissues, particularly in HCC. The high expression of PYGB (hazard ratios=1.801; 95% confidence interval: 1.266-2.562) could predict the poor prognosis of HCC patients but not PYGL and PYGM. Inhibition of PYGB with GP inhibitor CP91149 significantly suppressed the HCC cell proliferation in the HCC cell model. In addition, combination treatment with sorafenib, a standard treatment for HCC, showed a great inhibition on tumor growth and angiogenesis. These findings suggested that PYGB may be used as a therapeutic and prognostic indicator for HCC.
Identifiants
pubmed: 35761940
doi: 10.3892/ol.2022.13364
pii: OL-24-02-13364
pmc: PMC9214699
doi:
Types de publication
Journal Article
Langues
eng
Pagination
244Informations de copyright
Copyright: © Jiang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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