Plasma and Interstitial Fluid Pharmacokinetics of Prophylactic Cefazolin in Elective Bariatric Surgery Patients.

Anti-Bacterial Agents Bariatric Surgery Cefazolin Extracellular Fluid / metabolism Humans Obesity, Morbid / metabolism
antibiotic bariatric cefazolin population pharmacokinetics surgery

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
19 07 2022
Historique:
pubmed: 29 6 2022
medline: 22 7 2022
entrez: 28 6 2022
Statut: ppublish

Résumé

Guidelines for surgical prophylactic dosing of cefazolin in bariatric surgery vary in terms of recommended dose. This study aimed to describe the plasma and interstitial fluid (ISF) cefazolin pharmacokinetics in patients undergoing bariatric surgery and to determine an optimum dosing regimen. Abdominal subcutaneous ISF concentrations (measured using microdialysis) and plasma samples were collected at regular time points after administration of cefazolin 2 g intravenously. Total and unbound cefazolin concentrations were assayed and then modeled using Pmetrics. Monte Carlo dosing simulations (

Identifiants

DOI: 10.1128/aac.00419-22 PMID: 35762797 PMC: PMC9295570
pubmed: 35762797
doi: 10.1128/aac.00419-22
pmc: PMC9295570
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cefazolin IHS69L0Y4T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0041922

Références

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Auteurs

Rochelle L Ryan (RL)

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Department of Anaesthesia and Perioperative Medicine, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

Dwane Jackson (D)

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

George Hopkins (G)

Department of Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Victoria Eley (V)

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

Rebecca Christensen (R)

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

Andre A J Van Zundert (AAJ)

Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.
UQ Centre for Clinical Research, Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

Steven C Wallis (SC)

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.

Jeffrey Lipman (J)

Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.
UQ Centre for Clinical Research, Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.
Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.

Suzanne L Parker (SL)

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.
ORCID: 0000-0002-6124-7475

Jason A Roberts (JA)

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queenslandgrid.1003.2, Herston, Queensland, Australia.
Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Department of Pharmacy, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
ORCID: 0000-0001-6218-435X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Plasma and Interstitial Fluid Pharmacokinetics...
questionsmedicales.fr › Procédures de chirurgie opératoire › Chirurgie bariatrique › Plasma and Interstitial Fluid Pharmacokinetics...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfazoline › Plasma and Interstitial Fluid Pharmacokinetics...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Plasma and Interstitial Fluid Pharmacokinetics...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma and Interstitial Fluid Pharmacokinetics...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité morbide › Plasma and Interstitial Fluid Pharmacokinetics...