High-density EEG sleep correlates of cognitive and affective impairment at 12-month follow-up after COVID-19.

COVID-19 Cognition Electroencephalography Follow-Up Studies Humans Intensive Care Units Quality of Life Sleep / physiology
Electroencephalography Nap Neuropsychological assessment long COVID-19

Journal

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319

Informations de publication

Date de publication:
08 2022
Historique:
received: 05 04 2022
revised: 17 05 2022
accepted: 31 05 2022
pubmed: 29 6 2022
medline: 26 7 2022
entrez: 28 6 2022
Statut: ppublish

Résumé

To disentangle the pathophysiology of cognitive/affective impairment in Coronavirus Disease-2019 (COVID-19), we studied long-term cognitive and affective sequelae and sleep high-density electroencephalography (EEG) at 12-month follow-up in people with a previous hospital admission for acute COVID-19. People discharged from an intensive care unit (ICU) and a sub-intensive ward (nonICU) between March and May 2020 were contacted between March and June 2021. Participants underwent cognitive, psychological, and sleep assessment. High-density EEG recording was acquired during a nap. Slow and fast spindles density/amplitude/frequency and source reconstruction in brain gray matter were extracted. The relationship between psychological and cognitive findings was explored with Pearson correlation. We enrolled 33 participants ( 17 nonICU) and 12 controls. We observed a lower Physical Quality of Life index, higher post-traumatic stress disorder (PTSD) score, and a worse executive function performance in nonICU participants. Higher PTSD and Beck Depression Inventory scores correlated with lower executive performance. The same group showed a reorganization of spindle cortical generators. Our results show executive and psycho-affective deficits and spindle alterations in COVID-19 survivors - especially in nonICU participants - after 12 months from discharge. These findings may be suggestive of a crucial contribution of stress experienced during hospital admission on long-term cognitive functioning.

Identifiants

DOI: 10.1016/j.clinph.2022.05.017 PMID: 35763985 PMC: PMC9292469
pubmed: 35763985
pii: S1388-2457(22)00294-2
doi: 10.1016/j.clinph.2022.05.017
pmc: PMC9292469
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-135

Informations de copyright

Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Maria Rubega (M)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy. Electronic address: maria.rubega@unipd.it.

Luciana Ciringione (L)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy. Electronic address: luciana.ciringione@unipd.it.

Margherita Bertuccelli (M)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: margherita.bertuccelli@phd.unipd.it.

Matilde Paramento (M)

Department of Information Engineering, University of Padova, via Gradenigo 6/B, Padova 35131, Italy. Electronic address: matilde.paramento@studenti.unipd.it.

Giovanni Sparacino (G)

Department of Information Engineering, University of Padova, via Gradenigo 6/B, Padova 35131, Italy. Electronic address: gianni@dei.unipd.it.

Andrea Vianello (A)

Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, Padova 35128, Italy. Electronic address: andrea.vianello.1@unipd.it.

Stefano Masiero (S)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: stef.masiero@unipd.it.

Antonino Vallesi (A)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: antonino.vallesi@unipd.it.

Emanuela Formaggio (E)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: emanuela.formaggio@unipd.it.

Alessandra Del Felice (A)

Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: alessandra.delfelice@unipd.it.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électroencéphalographie › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › High-density EEG sleep correlates of cognitive...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › High-density EEG sleep correlates of cognitive...