COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
received:
17
01
2022
accepted:
31
05
2022
entrez:
28
6
2022
pubmed:
29
6
2022
medline:
1
7
2022
Statut:
epublish
Résumé
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December 28, 2020 to May 6, 2021 (Alpha (B.1.1.7) the predominant variant). We assessed illness (symptoms, duration, presentation to hospital) during Alpha- and Delta-predominant timeframes; and transmission, reinfection, and vaccine effectiveness during the Delta-predominant period. 3581 individuals (aged 18 to 100 years) from each timeframe were assessed. The seven most frequent symptoms were common to both variants. Within the first 28 days of illness, some symptoms were more common with Delta versus Alpha infection (including fever, sore throat, and headache) and some vice versa (dyspnoea). Symptom burden in the first week was higher with Delta versus Alpha infection; however, the odds of any given symptom lasting ≥ 7 days was either lower or unchanged. Illness duration ≥ 28 days was lower with Delta versus Alpha infection, though unchanged in unvaccinated individuals. Hospitalisation for COVID-19 was unchanged. The Delta variant appeared more (1.49) transmissible than Alpha. Re-infections were low in all UK regions. Vaccination markedly reduced the risk of Delta infection (by 69-84%). We conclude that COVID-19 from Delta or Alpha infections is similar. The Delta variant is more transmissible than Alpha; however, current vaccines showed good efficacy against disease. This research framework can be useful for future comparisons with new emerging variants.
Identifiants
pubmed: 35764879
doi: 10.1038/s41598-022-14016-0
pii: 10.1038/s41598-022-14016-0
pmc: PMC9240087
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10904Subventions
Organisme : Wellcome Trust
ID : WT213038/Z/18/Z
Pays : United Kingdom
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20059
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19027
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT203148/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
ID : MC_PC_19027
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20030
Pays : United Kingdom
Investigateurs
David M Aanensen
(DM)
Khalil Abudahab
(K)
Helen Adams
(H)
Alexander Adams
(A)
Safiah Afifi
(S)
Dinesh Aggarwal
(D)
Shazaad S Y Ahmad
(SSY)
Louise Aigrain
(L)
Adela Alcolea-Medina
(A)
Nabil-Fareed Alikhan
(NF)
Elias Allara
(E)
Roberto Amato
(R)
Adrienn Angyal
(A)
Tara Annett
(T)
Stephen Aplin
(S)
Cristina V Ariani
(CV)
Hibo Asad
(H)
Amy Ash
(A)
Paula Ashfield
(P)
Fiona Ashford
(F)
Laura Atkinson
(L)
Stephen W Attwood
(SW)
Cressida Auckland
(C)
Alp Aydin
(A)
David J Baker
(DJ)
Paul Baker
(P)
Carlos E Balcazar
(CE)
Jonathan Ball
(J)
Jeffrey C Barrett
(JC)
Magdalena Barrow
(M)
Edward Barton
(E)
Matthew Bashton
(M)
Andrew R Bassett
(AR)
Rahul Batra
(R)
Chris Baxter
(C)
Nadua Bayzid
(N)
Charlotte Beaver
(C)
Angela H Beckett
(AH)
Shaun M Beckwith
(SM)
Luke Bedford
(L)
Robert Beer
(R)
Andrew Beggs
(A)
Katherine L Bellis
(KL)
Louise Berry
(L)
Beatrice Bertolusso
(B)
Angus Best
(A)
Emma Betteridge
(E)
David Bibby
(D)
Kelly Bicknell
(K)
Debbie Binns
(D)
Alec Birchley
(A)
Paul W Bird
(PW)
Chloe Bishop
(C)
Rachel Blacow
(R)
Victoria Blakey
(V)
Beth Blane
(B)
Frances Bolt
(F)
James Bonfield
(J)
Stephen Bonner
(S)
David Bonsall
(D)
Tim Boswell
(T)
Andrew Bosworth
(A)
Yann Bourgeois
(Y)
Olivia Boyd
(O)
Declan T Bradley
(DT)
Cassie Breen
(C)
Catherine Bresner
(C)
Judith Breuer
(J)
Stephen Bridgett
(S)
Iraad F Bronner
(IF)
Ellena Brooks
(E)
Alice Broos
(A)
Julianne R Brown
(JR)
Giselda Bucca
(G)
Sarah L Buchan
(SL)
David Buck
(D)
Matthew Bull
(M)
Phillipa J Burns
(PJ)
Shirelle Burton-Fanning
(S)
Timothy Byaruhanga
(T)
Matthew Byott
(M)
Sharon Campbell
(S)
Alessandro M Carabelli
(AM)
James S Cargill
(JS)
Matthew Carlile
(M)
Sílvia F Carvalho
(SF)
Anna Casey
(A)
Anibolina Castigador
(A)
Jana Catalan
(J)
Vicki Chalker
(V)
Nicola J Chaloner
(NJ)
Meera Chand
(M)
Joseph G Chappell
(JG)
Themoula Charalampous
(T)
Wendy Chatterton
(W)
Yasmin Chaudhry
(Y)
Carol M Churcher
(CM)
Gemma Clark
(G)
Phillip Clarke
(P)
Benjamin J Cogger
(BJ)
Kevin Cole
(K)
Jennifer Collins
(J)
Rachel Colquhoun
(R)
Thomas R Connor
(TR)
Kate F Cook
(KF)
Jason Coombes
(J)
Sally Corden
(S)
Claire Cormie
(C)
Nicholas Cortes
(N)
Marius Cotic
(M)
Seb Cotton
(S)
Simon Cottrell
(S)
Lindsay Coupland
(L)
MacGregor Cox
(M)
Alison Cox
(A)
Noel Craine
(N)
Liam Crawford
(L)
Aidan Cross
(A)
Matthew R Crown
(MR)
Dorian Crudgington
(D)
Nicola Cumley
(N)
Tanya Curran
(T)
Martin D Curran
(MD)
Ana da Silva Filipe
(A)
Gavin Dabrera
(G)
Alistair C Darby
(AC)
Rose K Davidson
(RK)
Alisha Davies
(A)
Robert M Davies
(RM)
Thomas Davis
(T)
Daniela de Angelis
(D)
Elen De Lacy
(E)
Leonardo de Oliveira Martins
(L)
Thushan I de Silva
(TI)
Johnny Debebe
(J)
Rebecca Denton-Smith
(R)
Samir Dervisevic
(S)
Rebecca Dewar
(R)
Jayasree Dey
(J)
Joana Dias
(J)
Donald Dobie
(D)
Matthew J Dorman
(MJ)
Fatima Downing
(F)
Megan Driscoll
(M)
Louis du Plessis
(L)
Nichola Duckworth
(N)
Jillian Durham
(J)
Kirstine Eastick
(K)
Lisa J Easton
(LJ)
Richard Eccles
(R)
Jonathan Edgeworth
(J)
Sue Edwards
(S)
Kate El Bouzidi
(KE)
Sahar Eldirdiri
(S)
Nicholas Ellaby
(N)
Scott Elliott
(S)
Gary Eltringham
(G)
Leah Ensell
(L)
Michelle J Erkiert
(MJ)
Marina Escalera Zamudio
(ME)
Sarah Essex
(S)
Johnathan M Evans
(JM)
Cariad Evans
(C)
William Everson
(W)
Derek J Fairley
(DJ)
Karlie Fallon
(K)
Arezou Fanaie
(A)
Ben W Farr
(BW)
Christopher Fearn
(C)
Theresa Feltwell
(T)
Lynne Ferguson
(L)
Laia Fina
(L)
Flavia Flaviani
(F)
Vicki M Fleming
(VM)
Sally Forrest
(S)
Ebenezer Foster-Nyarko
(E)
Benjamin H Foulkes
(BH)
Luke Foulser
(L)
Mireille Fragakis
(M)
Dan Frampton
(D)
Sarah Francois
(S)
Christophe Fraser
(C)
Timothy M Freeman
(TM)
Helen Fryer
(H)
Marc Fuchs
(M)
William Fuller
(W)
Kavitha Gajee
(K)
Katerina Galai
(K)
Abbie Gallagher
(A)
Eileen Gallagher
(E)
Michael D Gallagher
(MD)
Marta Gallis
(M)
Amy Gaskin
(A)
Bree Gatica-Wilcox
(B)
Lily Geidelberg
(L)
Matthew Gemmell
(M)
Iliana Georgana
(I)
Ryan P George
(RP)
Laura Gifford
(L)
Lauren Gilbert
(L)
Sophia T Girgis
(ST)
Sharon Glaysher
(S)
Emily J Goldstein
(EJ)
Tanya Golubchik
(T)
Andrea N Gomes
(AN)
Sónia Gonçalves
(S)
Ian G Goodfellow
(IG)
Scott Goodwin
(S)
Salman Goudarzi
(S)
Marina Gourtovaia
(M)
Clive Graham
(C)
Lee Graham
(L)
Paul R Grant
(PR)
Luke R Green
(LR)
Angie Green
(A)
Jane Greenaway
(J)
Richard Gregory
(R)
Martyn Guest
(M)
Rory N Gunson
(RN)
Ravi K Gupta
(RK)
Bernardo Gutierrez
(B)
Sam T Haldenby
(ST)
William L Hamilton
(WL)
Samantha E Hansford
(SE)
Tanzina Haque
(T)
Kathryn A Harris
(KA)
Ian Harrison
(I)
Ewan M Harrison
(EM)
Jennifer Hart
(J)
John A Hartley
(JA)
William T Harvey
(WT)
Matthew Harvey
(M)
Mohammed O Hassan-Ibrahim
(MO)
Judith Heaney
(J)
Thomas Helmer
(T)
John H Henderson
(JH)
Andrew R Hesketh
(AR)
Jessica Hey
(J)
David Heyburn
(D)
Ellen E Higginson
(EE)
Verity Hill
(V)
Jack D Hill
(JD)
Rachel A Hilson
(RA)
Ember Hilvers
(E)
Matthew T G Holden
(MTG)
Amy Hollis
(A)
Christopher W Holmes
(CW)
Nadine Holmes
(N)
Alison H Holmes
(AH)
Richard Hopes
(R)
Hailey R Hornsby
(HR)
Myra Hosmillo
(M)
Catherine Houlihan
(C)
Hannah C Howson-Wells
(HC)
Sharon N Hsu
(SN)
Jonathan Hubb
(J)
Hannah Huckson
(H)
Warwick Hughes
(W)
Joseph Hughes
(J)
Margaret Hughes
(M)
Stephanie Hutchings
(S)
Giles Idle
(G)
Chris J Illingworth
(CJ)
Robert Impey
(R)
Dianne Irish-Tavares
(D)
Miren Iturriza-Gomara
(M)
Rhys Izuagbe
(R)
Chris Jackson
(C)
Ben Jackson
(B)
Leigh M Jackson
(LM)
Kathryn A Jackson
(KA)
David K Jackson
(DK)
Aminu S Jahun
(AS)
Victoria James
(V)
Keith James
(K)
Christopher Jeanes
(C)
Aaron R Jeffries
(AR)
Sarah Jeremiah
(S)
Andrew Jermy
(A)
Michaela John
(M)
Rob Johnson
(R)
Kate Johnson
(K)
Ian Johnston
(I)
Owen Jones
(O)
Sophie Jones
(S)
Hannah Jones
(H)
Christopher R Jones
(CR)
Neil Jones
(N)
Amelia Joseph
(A)
Sarah Judges
(S)
Gemma L Kay
(GL)
Sally Kay
(S)
Jon-Paul Keatley
(JP)
Alexander J Keeley
(AJ)
Anita Kenyon
(A)
Leanne M Kermack
(LM)
Manjinder Khakh
(M)
Stephen P Kidd
(SP)
Maimuna Kimuli
(M)
Stuart Kirk
(S)
Christine Kitchen
(C)
Katie Kitchman
(K)
Bridget A Knight
(BA)
Cherian Koshy
(C)
Moritz U G Kraemer
(MUG)
Sara Kumziene-Summerhayes
(S)
Dominic Kwiatkowski
(D)
Angie Lackenby
(A)
Kenneth G Laing
(KG)
Temi Lampejo
(T)
Cordelia F Langford
(CF)
Deborah Lavin
(D)
Andrew I Lawton
(AI)
Jack C D Lee
(JCD)
David Lee
(D)
Stefanie V Lensing
(SV)
Steven Leonard
(S)
Lisa J Levett
(LJ)
Thanh Le-Viet
(T)
Jonathan Lewis
(J)
Kevin Lewis
(K)
Jennifier Liddle
(J)
Steven Liggett
(S)
Patrick J Lillie
(PJ)
Benjamin B Lindsey
(BB)
Michelle M Lister
(MM)
Rich Livett
(R)
Stephanie Lo
(S)
Nicholas J Loman
(NJ)
Matthew W Loose
(MW)
Stavroula F Louka
(SF)
Katie F Loveson
(KF)
Sarah Lowdon
(S)
Hannah Lowe
(H)
Helen L Lowe
(HL)
Anita O Lucaci
(AO)
Catherine Ludden
(C)
Jessica Lynch
(J)
Ronan A Lyons
(RA)
Katrina Lythgoe
(K)
Nicholas W Machin
(NW)
George MacIntyre-Cockett
(G)
Andrew Mack
(A)
Ben Macklin
(B)
Alasdair Maclean
(A)
Emily Macnaughton
(E)
Pinglawathee Madona
(P)
Mailis Maes
(M)
Laurentiu Maftei
(L)
Adhyana I K Mahanama
(AIK)
Tabitha W Mahungu
(TW)
Daniel Mair
(D)
Joshua Maksimovic
(J)
Cassandra S Malone
(CS)
Daniel Maloney
(D)
Nikos Manesis
(N)
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(R)
Anna Mantzouratou
(A)
Angela Marchbank
(A)
Arun Mariappan
(A)
Inigo Martincorena
(I)
Rocio T Martinez Nunez
(RTM)
Alison E Mather
(AE)
Patrick Maxwell
(P)
Megan Mayhew
(M)
Tamyo Mbisa
(T)
Clare M McCann
(CM)
Shane A McCarthy
(SA)
Kathryn McCluggage
(K)
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(PC)
J T McCrone
(JT)
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(MP)
James P McKenna
(JP)
Caoimhe McKerr
(C)
Georgina M McManus
(GM)
Claire L McMurray
(CL)
Claire McMurray
(C)
Alan McNally
(A)
Lizzie Meadows
(L)
Nathan Medd
(N)
Oliver Megram
(O)
Mirko Menegazzo
(M)
Ian Merrick
(I)
Stephen L Michell
(SL)
Michelle L Michelsen
(ML)
Mariyam Mirfenderesky
(M)
Jeremy Mirza
(J)
Julia Miskelly
(J)
Emma Moles-Garcia
(E)
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(RJ)
Zoltan Molnar
(Z)
Irene M Monahan
(IM)
Matteo Mondani
(M)
Siddharth Mookerjee
(S)
Christopher Moore
(C)
Jonathan Moore
(J)
Nathan Moore
(N)
Catherine Moore
(C)
Helen Morcrette
(H)
Sian Morgan
(S)
Mari Morgan
(M)
Matilde Mori
(M)
Arthur Morriss
(A)
Samuel Moses
(S)
Craig Mower
(C)
Peter Muir
(P)
Afrida Mukaddas
(A)
Florence Munemo
(F)
Robert Munn
(R)
Abigail Murray
(A)
Leanne J Murray
(LJ)
Darren R Murray
(DR)
Manasa Mutingwende
(M)
Richard Myers
(R)
Eleni Nastouli
(E)
Gaia Nebbia
(G)
Andrew Nelson
(A)
Charlotte Nelson
(C)
Sam Nicholls
(S)
Jenna Nichols
(J)
Roberto Nicodemi
(R)
Kyriaki Nomikou
(K)
Justin O'Grady
(J)
Sarah O'Brien
(S)
Mina Odedra
(M)
Natasha Ohemeng-Kumi
(N)
Karen Oliver
(K)
Richard J Orton
(RJ)
Husam Osman
(H)
Áine O'Toole
(Á)
Nicole Pacchiarini
(N)
Debra Padgett
(D)
Andrew J Page
(AJ)
Emily J Park
(EJ)
Naomi R Park
(NR)
Matthew D Parker
(MD)
Surendra Parmar
(S)
David G Partridge
(DG)
David Pascall
(D)
Amita Patel
(A)
Bindi Patel
(B)
Steve Paterson
(S)
Brendan A I Payne
(BAI)
Sharon J Peacock
(SJ)
Clare Pearson
(C)
Emanuela Pelosi
(E)
Benita Percival
(B)
Jon Perkins
(J)
Malorie Perry
(M)
Malte L Pinckert
(ML)
Steven Platt
(S)
Olga Podplomyk
(O)
Manoj Pohare
(M)
Marcus Pond
(M)
Cassie F Pope
(CF)
Radoslaw Poplawski
(R)
Jessica Powell
(J)
Jennifer Poyner
(J)
Liam Prestwood
(L)
Anna Price
(A)
James R Price
(JR)
Jacqui A Prieto
(JA)
David T Pritchard
(DT)
Sophie J Prosolek
(SJ)
Georgia Pugh
(G)
Monika Pusok
(M)
Oliver G Pybus
(OG)
Hannah M Pymont
(HM)
Michael A Quail
(MA)
Joshua Quick
(J)
Clara Radulescu
(C)
Jayna Raghwani
(J)
Manon Ragonnet-Cronin
(M)
Lucille Rainbow
(L)
Diana Rajan
(D)
Shavanthi Rajatileka
(S)
Newara A Ramadan
(NA)
Andrew Rambaut
(A)
John Ramble
(J)
Paul A Randell
(PA)
Paul Randell
(P)
Liz Ratcliffe
(L)
Veena Raviprakash
(V)
Mohammad Raza
(M)
Nicholas M Redshaw
(NM)
Sara Rey
(S)
Nicola Reynolds
(N)
Alex Richter
(A)
David L Robertson
(DL)
Esther Robinson
(E)
Samuel C Robson
(SC)
Fiona Rogan
(F)
Stefan Rooke
(S)
Will Rowe
(W)
Sunando Roy
(S)
Steven Rudder
(S)
Chris Ruis
(C)
Steven Rushton
(S)
Felicity Ryan
(F)
Kordo Saeed
(K)
Buddhini Samaraweera
(B)
Christine M Sambles
(CM)
Roy Sanderson
(R)
Theo Sanderson
(T)
Fei Sang
(F)
Thea Sass
(T)
Emily Scher
(E)
Garren Scott
(G)
Carol Scott
(C)
Jasveen Sehmi
(J)
Sharif Shaaban
(S)
Divya Shah
(D)
Jessica Shaw
(J)
Ekaterina Shelest
(E)
James G Shepherd
(JG)
Liz A Sheridan
(LA)
Nicola Sheriff
(N)
Lesley Shirley
(L)
John Sillitoe
(J)
Siona Silviera
(S)
David A Simpson
(DA)
Aditi Singh
(A)
Dawn Singleton
(D)
Timofey Skvortsov
(T)
Tim J Sloan
(TJ)
Graciela Sluga
(G)
Ken Smith
(K)
Kim S Smith
(KS)
Perminder Smith
(P)
Darren L Smith
(DL)
Louise Smith
(L)
Colin P Smith
(CP)
Nikki Smith
(N)
Katherine L Smollett
(KL)
Luke B Snell
(LB)
Thomas Somassa
(T)
Joel Southgate
(J)
Karla Spellman
(K)
Michael H Spencer Chapman
(MHS)
Lewis G Spurgin
(LG)
Moira J Spyer
(MJ)
Rachael Stanley
(R)
William Stanley
(W)
Thomas D Stanton
(TD)
Igor Starinskij
(I)
Joanne Stockton
(J)
Susanne Stonehouse
(S)
Nathaniel Storey
(N)
David J Studholme
(DJ)
Malur Sudhanva
(M)
Emma Swindells
(E)
Yusri Taha
(Y)
Ngee Keong Tan
(NK)
Julian W Tang
(JW)
Miao Tang
(M)
Ben E W Taylor
(BEW)
Joshua F Taylor
(JF)
Sarah Taylor
(S)
Ben Temperton
(B)
Kate E Templeton
(KE)
Claire Thomas
(C)
Laura Thomson
(L)
Emma C Thomson
(EC)
Alicia Thornton
(A)
Scott A J Thurston
(SAJ)
John A Todd
(JA)
Rachael Tomb
(R)
Lily Tong
(L)
Gerry Tonkin-Hill
(G)
M Estee Torok
(ME)
Jaime M Tovar-Corona
(JM)
Amy Trebes
(A)
Alexander J Trotter
(AJ)
Ioulia Tsatsani
(I)
Robyn Turnbull
(R)
Lance Turtle
(L)
Katherine A Twohig
(KA)
Helen Umpleby
(H)
Anthony P Underwood
(AP)
Edith E Vamos
(EE)
Tetyana I Vasylyeva
(TI)
Sreenu Vattipally
(S)
Gabrielle Vernet
(G)
Barry B Vipond
(BB)
Erik M Volz
(EM)
Sarah Walsh
(S)
Dennis Wang
(D)
Ben Warne
(B)
Joanna Warwick-Dugdale
(J)
Elizabeth Wastnedge
(E)
Joanne Watkins
(J)
Louisa K Watson
(LK)
Sheila Waugh
(S)
Hermione J Webster
(HJ)
Danni Weldon
(D)
Elaine Westwick
(E)
Thomas Whalley
(T)
Helen Wheeler
(H)
Mark Whitehead
(M)
Max Whiteley
(M)
Andrew Whitwham
(A)
Claudia Wierzbicki
(C)
Nicholas J Willford
(NJ)
Lesley-Anne Williams
(LA)
Rebecca Williams
(R)
Cheryl Williams
(C)
Chris Williams
(C)
Charlotte A Williams
(CA)
Rachel J Williams
(RJ)
Thomas Williams
(T)
Catryn Williams
(C)
Kathleen A Williamson
(KA)
Eleri Wilson-Davies
(E)
Eric Witele
(E)
Karen T Withell
(KT)
Adam A Witney
(AA)
Paige Wolverson
(P)
Nick Wong
(N)
Trudy Workman
(T)
Victoria Wright
(V)
Derek W Wright
(DW)
Tim Wyatt
(T)
Sarah Wyllie
(S)
Li Xu-McCrae
(L)
Mehmet Yavus
(M)
Geraldine Yaze
(G)
Corin A Yeats
(CA)
Gonzalo Yebra
(G)
Wen C Yew
(WC)
Gregory R Young
(GR)
Jamie Young
(J)
Alex E Zarebski
(AE)
Peijun Zhang
(P)
Informations de copyright
© 2022. The Author(s).
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