Emerging role of exosomes in cancer progression and tumor microenvironment remodeling.
Biomarker
Cancer
Exosome
Immunotherapy
Non-coding RNA
Prognosis
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
received:
30
01
2022
accepted:
13
06
2022
entrez:
28
6
2022
pubmed:
29
6
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment.
Identifiants
pubmed: 35765040
doi: 10.1186/s13045-022-01305-4
pii: 10.1186/s13045-022-01305-4
pmc: PMC9238168
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
83Subventions
Organisme : Singapore Ministry of Education Tier 2
ID : MOE-T2EP30120-0016
Organisme : Universiti Kebangsaan Malaysia
ID : GUP-2020-076
Organisme : Ministry of Higher Education, Malaysia
ID : FRGS/1/2019/SKK08/UKM/02/9
Informations de copyright
© 2022. The Author(s).
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