Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice.
Aging
Aquaporin-4
Endfeet
Glial progenitor cells
Sensory response
Transplantation
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
received:
04
11
2021
accepted:
05
06
2022
entrez:
28
6
2022
pubmed:
29
6
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Aging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial progenitor cell (GPC) derived astrocytes remained unknown. In the current study, GPCs were generated from embryonic cortical neural stem cells in vitro and transplanted into the brains of aged mice. Their integration and intervention effects in the aged brain were examined 12 months after transplantation. Results indicated that these in-vitro-generated GPC-derived astrocytes possessed normal functional properties. After transplantation they could migrate, differentiate, achieve long-term integration, and maintain much younger morphology in the aged brain. Additionally, these GPC-derived astrocytes established endfeet expressing aquaporin-4 (AQP4) and ameliorate AQP4 polarization in the aged neocortex. More importantly, age-dependent sensory response degeneration was reversed by GPC transplantation. This work demonstrates that rejuvenation of the astrocyte niche is a promising treatment to prevent age-induced degradation of neuronal and behavioral functions.
Identifiants
pubmed: 35765112
doi: 10.1186/s13287-022-02959-0
pii: 10.1186/s13287-022-02959-0
pmc: PMC9241208
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
285Informations de copyright
© 2022. The Author(s).
Références
Int J Mol Med. 2018 Oct;42(4):1935-1944
pubmed: 30085336
Brain Struct Funct. 2015;220(3):1681-93
pubmed: 24659256
J Neurosci. 2014 Nov 26;34(48):16153-61
pubmed: 25429155
Cereb Cortex. 2009 Jul;19(7):1530-8
pubmed: 19008462
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3948-52
pubmed: 7732010
Pflugers Arch. 2021 May;473(5):753-774
pubmed: 32979108
Sci Rep. 2016 Mar 04;6:22605
pubmed: 26940982
J Clin Invest. 2015 Mar 2;125(3):1033-42
pubmed: 25642771
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Front Aging Neurosci. 2018 Oct 26;10:337
pubmed: 30416441
Neuron. 2014 Sep 03;83(5):1058-72
pubmed: 25155958
Science. 2000 Feb 25;287(5457):1433-8
pubmed: 10688783
Int Rev Cell Mol Biol. 2021;362:1-53
pubmed: 34253292
Nat Commun. 2013;4:2196
pubmed: 23880652
Cell Rep. 2020 May 19;31(7):107658
pubmed: 32433967
Neuroreport. 1996 Apr 10;7(5):1009-12
pubmed: 8804041
Nat Commun. 2016 Jun 07;7:11758
pubmed: 27273432
J Neurophysiol. 1998 Apr;79(4):2119-48
pubmed: 9535973
Neurosci Bull. 2020 May;36(5):530-544
pubmed: 31828740
Cereb Cortex. 2020 Nov 3;30(12):6296-6312
pubmed: 32691053
Stem Cells. 2006 Sep;24(9):2110-9
pubmed: 16728559
Neuron. 2016 Dec 21;92(6):1181-1195
pubmed: 27939582
Front Aging Neurosci. 2019 Mar 19;11:59
pubmed: 30941031
PLoS One. 2018 Jul 2;13(7):e0198131
pubmed: 29966021
Glia. 2017 Dec;65(12):1867-1884
pubmed: 28631858
Cell Stem Cell. 2013 Mar 7;12(3):342-53
pubmed: 23472873
Glia. 2006 Nov 15;54(7):716-25
pubmed: 17006900
Cell Stem Cell. 2013 Feb 7;12(2):252-64
pubmed: 23395447
J Cereb Blood Flow Metab. 2014 Jul;34(7):1138-47
pubmed: 24714034
Aging Cell. 2021 Mar;20(3):e13334
pubmed: 33675569
Exp Neurol. 2016 Sep;283(Pt B):476-88
pubmed: 27170209
Cereb Cortex. 2016 Sep;26(9):3690-3704
pubmed: 27405333
Aging Cell. 2019 Jun;18(3):e12937
pubmed: 30815970
Neuropathol Appl Neurobiol. 2017 Oct;43(6):477-491
pubmed: 28039950
Neuroscience. 2016 May 26;323:170-82
pubmed: 25595973
Glia. 1999 Jan 15;25(2):111-9
pubmed: 9890626
Cell Stem Cell. 2015 Feb 5;16(2):198-210
pubmed: 25658373
Neuroscience. 2001;104(3):705-15
pubmed: 11440803
J Neurosci. 1995 Apr;15(4):2961-71
pubmed: 7722640
Stem Cells. 2018 Aug;36(8):1179-1197
pubmed: 29575325
Nat Neurosci. 2008 Nov;11(11):1294-301
pubmed: 18931666
Cold Spring Harb Perspect Biol. 2014 Dec 11;7(3):a020438
pubmed: 25502516
Science. 2012 Oct 26;338(6106):491-5
pubmed: 23112326
Exp Neurol. 2016 Jun;280:41-9
pubmed: 27032721
Exp Gerontol. 2017 Aug;94:52-58
pubmed: 27845201
Prog Brain Res. 2017;231:165-189
pubmed: 28554396
PLoS One. 2008;3(10):e3399
pubmed: 18852896
Ann Neurol. 2014 Dec;76(6):845-61
pubmed: 25204284