Investigating the association of mood and fatigue with objective and subjective cognitive impairment in multiple sclerosis.
cognitive function
depression
fatigue
multiple sclerosis
neuropsychology
Journal
Journal of neuropsychology
ISSN: 1748-6653
Titre abrégé: J Neuropsychol
Pays: England
ID NLM: 101468753
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
27
10
2021
accepted:
01
06
2022
pubmed:
30
6
2022
medline:
9
9
2022
entrez:
29
6
2022
Statut:
ppublish
Résumé
Discrepancies between subjective cognitive difficulties and objective measures of cognitive function in people with MS have been identified and may be related to mood and fatigue. The aim of the present study was to examine associations of depression and fatigue with discrepancies between subjective and objective cognitive functioning in pwMS. 177 participants with MS attending a University Hospital Department of Neurology MS Outpatient clinic completed the Brief International Cognitive Assessment for MS (BICAMS), MS Neuropsychological Questionnaire (MSNQ), Hospital Anxiety and Depression Scale (HADS) and Modified Fatigue Impact Scale (MFIS). To quantify the discrepancy between objective (BICAMS) and subjective (MSNQ) cognitive functioning, discrepancy scores were calculated by subtracting MSNQ z-score from composite BICAMS z-score. Based on their discrepancy score, participants were grouped as 'Underestimated', 'Overestimated' and 'Non-discrepant'. 39% of the total sample demonstrated poorer subjective cognitive functioning than their objective cognitive performance suggested ('Underestimated'). 23% of the total sample indicated lower objective scores than their subjective report suggests ('Overestimated'). 38% participants indicated relatively no discrepancy between objective and subjective cognitive measures ('Non-discrepant'). Significant differences were observed between the discrepancy groups in terms of depression and fatigue, with the 'Underestimated' group demonstrating greater levels of depression and fatigue (ps < .01). Regression analysis indicated that cognitive fatigue and depression significantly contributed to variance in subjective cognitive functioning. Our findings suggest that subjective reports of cognitive function may be influenced by depression and fatigue, emphasising the importance of cognitive, mood and fatigue screening as part of routine clinical care.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
537-554Informations de copyright
© 2022 The British Psychological Society.
Références
Bailey, A., Channon, S., & Beaumont, J. G. (2007). The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis. Multiple Sclerosis Journal, 13(1), 73-80.
Beier, M., Gromisch, E. S., Hughes, A. J., Alschuler, K. N., Madathil, R., Chiaravalloti, N., & Foley, F. W. (2017). Proposed cut scores for tests of the brief international cognitive assessment of multiple sclerosis (BICAMS). Journal of the Neurological Sciences, 381, 110-116.
Benedict, R. H. (1997). Brief visuospatial memory test-Revised: Professional manual. Psychological Assessment Resources, Inc.
Benedict, R. H., Amato, M. P., Boringa, J., Brochet, B., Foley, F., Fredrikson, S., & Langdon, D. (2012). Brief international cognitive assessment for MS (BICAMS): International standards for validation. BMC Neurology, 12(1), 1-7.
Benedict, R. H., Cox, D., Thompson, L. L., Foley, F., Weinstock-Guttman, B., & Munschauer, F. (2004). Reliable screening for neuropsychological impairment in multiple sclerosis. Multiple Sclerosis Journal, 10(6), 675-678.
Benedict, R. H., Munschauer, F., Linn, R., Miller, C., Murphy, E., Foley, F., & Jacobs, L. J. M. S. J. (2003). Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Multiple Sclerosis Journal, 9(1), 95-101.
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002). The validity of the hospital anxiety and depression scale: An updated literature review. Journal of Psychosomatic Research, 52(2), 69-77.
Boeschoten, R. E., Braamse, A. M., Beekman, A. T., Cuijpers, P., van Oppen, P., Dekker, J., & Uitdehaag, B. M. (2017). Prevalence of depression and anxiety in multiple sclerosis: A systematic review and meta-analysis. Journal of the Neurological Sciences, 372, 331-341.
Bol, Y., Duits, A. A., Hupperts, R. M., Verlinden, I., & Verhey, F. R. (2010). The impact of fatigue on cognitive functioning in patients with multiple sclerosis. Clinical Rehabilitation, 24(9), 854-862.
Borragán, G., Gilson, M., Atas, A., Slama, H., Lysandropoulos, A., De Schepper, M., & Peigneux, P. (2018). Cognitive fatigue, sleep and cortical activity in multiple sclerosis disease. A behavioral, polysomnographic and functional near-infrared spectroscopy investigation. Frontiers in Human Neuroscience, 12, 378.
Brassington, J. C., & Marsh, N. V. (1998). Neuropsychological aspects of multiple sclerosis. Neuropsychology Review, 8(2), 43-77.
Brenner, P., & Piehl, F. (2016). Fatigue and depression in multiple sclerosis: Pharmacological and non-pharmacological interventions. Acta Neurologica Scandinavica, 134, 47-54.
Campbell, J., Rashid, W., Cercignani, M., & Langdon, D. (2017). Cognitive impairment among patients with multiple sclerosis: Associations with employment and quality of life. Postgraduate Medical Journal, 93(1097), 143-147.
Carone, D. A., Benedict, R. H. B., Iii, F. M., Fishman, I., & Weinstock-Guttman, B. (2005). Interpreting patient/informant discrepancies of reported cognitive symptoms in MS. Journal of the International Neuropsychological Society: JINS, 11(5), 574-583.
Clare, L., Marková, I. S., Roth, I., & Morris, R. G. (2011). Awareness in Alzheimer's disease and associated dementias: Theoretical framework and clinical implications. Aging & Mental Health, 15(8), 936-944.
Corfield, F., & Langdon, D. (2018). A systematic review and meta-analysis of the brief cognitive assessment for multiple sclerosis (BICAMS). Neurology and Therapy, 7(2), 287-306.
D'hooghe, M. B., De Cock, A., Benedict, R. H. B., Gielen, J., Van Remoortel, A., Eelen, P., & Nagels, G. (2019). Perceived neuropsychological impairment inversely related to self-reported health and employment in multiple sclerosis. European Journal of Neurology, 26(12), 1447-1454.
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2000). California verbal learning test manual: Second Edition, Adult Version. Psychological Corporation.
Demaree, H., Gaudino, E., & DeLuca, J. (2003). The relationship between depressive symptoms and cognitive dysfunction in multiple sclerosis. Cognitive Neuropsychiatry, 8(3), 161-171.
Feinstein, A., Magalhaes, S., Richard, J. F., Audet, B., & Moore, C. (2014). The link between multiple sclerosis and depression. Nature Reviews Neurology, 10(9), 507-517.
Fiest, K. M., Walker, J. R., Bernstein, C. N., Graff, L. A., Zarychanski, R., Abou-Setta, A. M., & Marrie, R. A. (2016). Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders, 5, 12-26.
Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J. (1994). The impact of fatigue on patients with multiple sclerosis. Canadian Journal of Neurological Sciences, 21(1), 9-14.
Flachenecker, P., Kümpfel, T., Kallmann, B., Gottschalk, M., Grauer, O., Rieckmann, P., & Toyka, K. V. (2002). Fatigue in multiple sclerosis: A comparison of different rating scales and correlation to clinical parameters. Multiple Sclerosis Journal, 8(6), 523-526.
Goverover, Y., Chen, M. H., Costa, S. L., Chiaravalloti, N. D., & DeLuca, J. (2020). Smell as a clinical-marker for functional limitations in multiple sclerosis: A pilot study. Multiple Sclerosis and Related Disorders, 46, 102508.
Guilloton, L., Camdessanche, J. P., Latombe, D., Neuschwander, P., Cantalloube, S., Thomas-Anterion, C., & Jacquin-Courtois, S. (2020). A clinical screening tool for objective and subjective cognitive disorders in multiple sclerosis. Annals of Physical and Rehabilitation Medicine, 63(2), 116-122.
Holtzer, R., & Foley, F. (2009). The relationship between subjective reports of fatigue and executive control in multiple sclerosis. Journal of the Neurological Sciences, 281(1-2), 46-50.
Hsu, K. J., & Davison, G. C. (2017). Compounded deficits: The association between neuropsychological impairment and attention biases in currently depressed, formerly depressed, and never depressed individuals. Clinical Psychological Science, 5(2), 286-298.
Hughes, A. J., Bhattarai, J. J., Paul, S., & Beier, M. (2019). Depressive symptoms and fatigue as predictors of objective-subjective discrepancies in cognitive function in multiple sclerosis. Multiple Sclerosis and Related Disorders, 30, 192-197.
Julian, L., Merluzzi, N. M., & Mohr, D. C. (2007). The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis. Multiple Sclerosis Journal, 13(1), 81-86.
Khan, F., Amatya, B., & Galea, M. (2014). Management of fatigue in persons with multiple sclerosis. Frontiers in Neurology, 5, 177.
Kinsinger, S. W., Lattie, E., & Mohr, D. C. (2010). Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis. Neuropsychology, 24(5), 573-580.
Kos, D., Kerckhofs, E., Carrea, I., Verza, R., Ramos, M., & Jansa, J. (2005). Evaluation of the modified fatigue impact scale in four different European countries. Multiple Sclerosis Journal, 11(1), 76-80.
Kroenke, K., Strine, T. W., Spitzer, R. L., Williams, J. B., Berry, J. T., & Mokdad, A. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1-3), 163-173, 173.
Krupp, L. (2006). Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease. Multiple Sclerosis, 12(4), 367-368.
Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46(10), 1121-1123.
Langdon, D. W., Amato, M. P., Boringa, J., Brochet, B., Foley, F., Fredrikson, S., & Reder, A. T. (2012). Recommendations for a brief international cognitive assessment for multiple sclerosis (BICAMS). Multiple Sclerosis Journal, 18(6), 891-898.
Linnhoff, S., Fiene, M., Heinze, H. J., & Zaehle, T. (2019). Cognitive fatigue in multiple sclerosis: An objective approach to diagnosis and treatment by transcranial electrical stimulation. Brain Sciences, 9(5), 100.
Lovera, J., Bagert, B., Smoot, K. H., Wild, K., Frank, R., Bogardus, K., & Bourdette, D. N. (2006). Correlations of perceived deficits questionnaire of multiple sclerosis quality of life inventory with Beck depression inventory and neuropsychological tests. Journal of Rehabilitation Research & Development, 43(1), 73-82.
Macías Islas, M. Á., & Ciampi, E. (2019). Assessment and impact of cognitive impairment in multiple sclerosis: An overview. Biomedicine, 7(1), 22.
Marstrand, L., Østerberg, O., Walsted, T., Skov, A. C., Schreiber, K. I., & Sellebjerg, F. (2020). Brief international cognitive assessment for multiple sclerosis (BICAMS): A Danish validation study of sensitivity in early stages of MS. Multiple Sclerosis and Related Disorders, 37, 101458.
McNicholas, N., Tubridy, N., Hutchinson, M., & McGuigan, C. (2021). Perceived and objective cognitive impairment in newly diagnosed versus established multiple sclerosis: Impact of disease duration. Irish Journal of Medical Science, 190(3), 1149-1154.
Middleton, L. S., Denney, D. R., Lynch, S. G., & Parmenter, B. (2006). The relationship between perceived and objective cognitive functioning in multiple sclerosis. Archives of Clinical Neuropsychology, 21(5), 487-494.
Mills, R. J., Young, C. A., Pallant, J. F., & Tennant, A. (2010). Rasch analysis of the modified fatigue impact scale (MFIS) in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 81(9), 1049-1051.
Mohr, D. C., Goodkin, D. E., Likosky, W., Gatto, N., Baumann, K. A., & Rudick, R. A. (1997). Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Archives of Neurology, 54(5), 531-533.
Morrow, S. A., Drake, A., Zivadinov, R., Munschauer, F., Weinstock-Guttman, B., & Benedict, R. H. (2010). Predicting loss of employment over three years in multiple sclerosis: Clinically meaningful cognitive decline. The Clinical Neuropsychologist, 24(7), 1131-1145.
O'Connell, K., Langdon, D., Tubridy, N., Hutchinson, M., & McGuigan, C. (2015). A preliminary validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS). Multiple Sclerosis and Related Disorders, 4(6), 521-525.
O'Keeffe, F. M., Murray, B., Coen, R. F., Dockree, P. M., Bellgrove, M. A., Garavan, H., & Robertson, I. H. (2007). Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy. Brain, 130(3), 753-764.
Ozakbas, S., Yigit, P., Cinar, B. P., Limoncu, H., Kahraman, T., & Kösehasanogullari, G. (2017). The Turkish validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) battery. BMC Neurology, 17(1), 208-206. https://doi.org/10.1186/s12883-017-0993-0
Parmenter, B. A., Denney, D. R., & Lynch, S. G. (2003). The cognitive performance of patients with multiple sclerosis during periods of high and low fatigue. Multiple Sclerosis Journal, 9(2), 111-118.
Persson, R., Lee, S., Yood, M. U., Wagner, M. R., Minton, N., Niemcryk, S., & Jick, S. (2020). Incident depression in patients diagnosed with multiple sclerosis: A multi- database study. European Journal of Neurology, 27(8), 1556-1560.
Rabinowitz, A. R., & Arnett, P. A. (2009). A longitudinal analysis of cognitive dysfunction, coping, and depression in multiple sclerosis. Neuropsychology, 23(5), 581-591.
Renner, A., Baetge, S. J., Filser, M., Ullrich, S., Lassek, C., & Penner, I. K. (2020). Characterizing cognitive deficits and potential predictors in multiple sclerosis: A large nationwide study applying brief international cognitive assessment for multiple sclerosis in standard clinical care. Journal of Neuropsychology, 14(3), 347-369.
Rosti-Otajärvi, E., Ruutiainen, J., Huhtala, H., & Hämäläinen, P. (2014). Relationship between subjective and objective cognitive performance in multiple sclerosis. Acta Neurologica Scandinavica, 130(5), 319-327.
Smith, A. (1982). Symbol digit modalities test: Manual. Western Psychological Services.
Sousa, C., Rigueiro-Neves, M., Miranda, T., Alegria, P., Vale, J., Passos, A. M., Langdon, D., & Sá, M. J. (2018). Validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) in the Portuguese population with multiple sclerosis. BMC Neurology, 18(1), 172. https://doi.org/10.1186/s12883-018-1175-4
Sullivan, M. J., Edgley, K., & Dehoux, E. (1990). A survey of multiple sclerosis: I. perceived cognitive problems and compensatory strategy use. Canadian Journal of Rehabilitation, 4(2), 99-105.
Sumowski, J. F., & Leavitt, V. M. (2013). Cognitive reserve in multiple sclerosis. Multiple Sclerosis Journal, 19(9), 1122-1127.
Weinges-Evers, N., Brandt, A. U., Bock, M., Pfueller, C. F., Dörr, J., Bellmann-Strobl, J., & Paul, F. (2010). Correlation of self-assessed fatigue and alertness in multiple sclerosis. Multiple Sclerosis Journal, 16(9), 1134-1140.
Yigit, P., Acikgoz, A., Mehdiyev, Z., Dayi, A., & Ozakbas, S. (2021). The relationship between cognition, depression, fatigue, and disability in patients with multiple sclerosis. Irish Journal of Medical Science, 190(3), 1129-1136.
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361-370.