Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes.
Journal
International journal of dermatology
ISSN: 1365-4632
Titre abrégé: Int J Dermatol
Pays: England
ID NLM: 0243704
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
17
04
2022
received:
29
06
2021
accepted:
13
06
2022
pubmed:
30
6
2022
medline:
16
11
2022
entrez:
29
6
2022
Statut:
ppublish
Résumé
Patients with hypertrophic lichen planus (HLP) and squamous cell carcinoma (SCC) diagnoses present clinicians with diagnostic and disease management challenges. To better define the clinical and treatment outcomes of patients with concomitant diagnoses of HLP and SCC. A retrospective review was performed from January 1, 2008, to July 31, 2015, at Mayo Clinic. Patients with a histologic diagnosis of HLP and SCC were included. Patient demographics, associated comorbidities, histopathologic characteristics, treatment, and outcomes were evaluated. Thirty-three patients were identified; 79% were female, and mostly the lower extremities were involved. Most of the SCCs were well-differentiated and in situ with the majority treated with destruction or excision. There were no cases of local recurrence, metastasis, or disease-specific death during the follow-up period (mean 55.8 months). Patients with diagnoses of both HLP and SCC appear to be a distinct population that is predominantly female with lesion predilection for the lower extremities. However, regardless of treatment modality or tumor size, there were no adverse outcomes. An initial trial of more conservative treatment measures with close follow-up may be reasonable with biopsy of lesions unresponsive to conventional treatment.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with hypertrophic lichen planus (HLP) and squamous cell carcinoma (SCC) diagnoses present clinicians with diagnostic and disease management challenges.
OBJECTIVE
OBJECTIVE
To better define the clinical and treatment outcomes of patients with concomitant diagnoses of HLP and SCC.
METHODS AND MATERIALS
METHODS
A retrospective review was performed from January 1, 2008, to July 31, 2015, at Mayo Clinic. Patients with a histologic diagnosis of HLP and SCC were included. Patient demographics, associated comorbidities, histopathologic characteristics, treatment, and outcomes were evaluated.
RESULTS
RESULTS
Thirty-three patients were identified; 79% were female, and mostly the lower extremities were involved. Most of the SCCs were well-differentiated and in situ with the majority treated with destruction or excision. There were no cases of local recurrence, metastasis, or disease-specific death during the follow-up period (mean 55.8 months).
CONCLUSION
CONCLUSIONS
Patients with diagnoses of both HLP and SCC appear to be a distinct population that is predominantly female with lesion predilection for the lower extremities. However, regardless of treatment modality or tumor size, there were no adverse outcomes. An initial trial of more conservative treatment measures with close follow-up may be reasonable with biopsy of lesions unresponsive to conventional treatment.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1527-1531Informations de copyright
© 2022 the International Society of Dermatology.
Références
Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009; 48(7): 682-94.
Bolognia J, Jorizzo JL, Schaffer JV. Dermatology. 3rd ed. Philadelphia (PA): Elsevier Saunders; 2012.
James WD, Elston DM, Berger TG, Andrews GC. Andrews' diseases of the skin: clinical dermatology. 11th ed. London (UK): Elsevier Saunders; 2011.
Rippis GE, Becker B, Scott G. Hypertrophic lichen planus in three HIV-positive patients: a histologic and immunological study. J Cutan Pathol. 1994; 21: 52-8.
Daramola OOM, Ogunbiyi AO, George AO. Evaluation of clinical types of cutaneous lichen planus in anti-hepatitis C virus seronegative and seropositive Nigerian patients. Int J Dermatol. 2003; 42: 933-5.
Weedon D, Strutton G, Rubin AI, Weedon D. Weedon's skin pathology. 3rd ed. Edinburgh (UK): Churchill Livingstone/Elsevier; 2010.
Knackstedt TJ, Collins LK, Li Z, Yan S, Samie FH. Squamous cell carcinoma arising in hypertrophic lichen planus: a review and analysis of 38 cases. Dermatol Surg. 2015; 41: 1411-8.
Manz B, Paasch U, Sticherling M. Squamous cell carcinoma as a complication of long-standing hypertrophic lichen planus. Int J Dermatol. 2005; 44(9): 773-4.
Sigurgeirsson B, Lindelöf B. Lichen planus and malignancy. An epidemiologic study of 2071 patients and a review of the literature. Arch Dermatol. 1991; 127(11): 1684-8.
Speziali L, Pusiol T, Zorzi MG, Morichetti D, Zumiani G. Pseudoepitheliomatous hyperplasia arising from hypertrophic lichen planus mimicking squamous cell carcinoma. G Ital Dermatol Venereol. 2011 Aug; 146(4): 310-1.
Pusiol T, Zorzi MG, Morichetti D, Speziali L. Pseudoepitheliomatous hyperplasia arising from hypertrophic lichen planus mimicking squamous cell carcinoma: limited value of immunohistochemistry. Acta Dermatovenerol Croat. 2012; 20(2): 112-4.
Astudillo MG, Hoang MP, Nazarian RM, Foreman RK. Distinction between hypertrophic lichen planus and squamous cell carcinoma requires clinicopathologic correlation in difficult cases. Am J Dermatopathol. 2021; 43(5): 349-55.
Kathuria S, Karmakar S, Singh A, Singh SP. Squamous Cell Carcinoma Arising from Hypertrophic Lichen Planus. Indian. Dermatol Online J. 2017; 8(4): 288-90. https://doi.org/10.4103/2229-5178.209617
Munday WR, Leffell DJ, McNiff JM, et al. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. J Cutan Pathol. 2016; 43(9): 759-65.