Cancer risk and tumour spectrum in 172 patients with a germline

central nervous system diseases congenital, hereditary, and neonatal diseases and abnormalities genetic counseling genetic predisposition to disease germ-line mutation

Journal

Journal of medical genetics
ISSN: 1468-6244
Titre abrégé: J Med Genet
Pays: England
ID NLM: 2985087R

Informations de publication

Date de publication:
29 Jun 2022
Historique:
received: 10 01 2022
accepted: 23 04 2022
entrez: 29 6 2022
pubmed: 30 6 2022
medline: 30 6 2022
Statut: aheadofprint

Résumé

Little is known about risks associated with germline To study tumour risks, we have analysed data of a large cohort of 45 unpublished patients with a germline Overall, 117/172 (68%) Germline

Sections du résumé

BACKGROUND BACKGROUND
Little is known about risks associated with germline
METHODS METHODS
To study tumour risks, we have analysed data of a large cohort of 45 unpublished patients with a germline
RESULTS RESULTS
Overall, 117/172 (68%)
CONCLUSION CONCLUSIONS
Germline

Identifiants

pubmed: 35768194
pii: jmedgenet-2021-108385
doi: 10.1136/jmedgenet-2021-108385
pmc: PMC9613872
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Léa Guerrini-Rousseau (L)

Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, France lea.guerrini-rousseau@gustaveroussy.fr.
Team "Genomics and Oncogenesis of pediatric Brain Tumors"-Paris Saclay University, INSERM U981, VILLEJUIF, France.

Julien Masliah-Planchon (J)

INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Institute Curie, Paris, France.

Sebastian M Waszak (SM)

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.
Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.

Pia Alhopuro (P)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

Patrick R Benusiglio (PR)

Département de Génétique et Institut Universitaire de Cancérologie, Sorbonne University Faculty of Medicine Pitié-Salpêtrière Campus, Paris, France.

Franck Bourdeaut (F)

INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Institute Curie, Paris, France.

Ines B Brecht (IB)

Department of Pediatric Oncology and Hematology, University Hospitals Tubingen, Tubingen, Germany.

Giada Del Baldo (G)

Department of Hematology/Oncology, Cell Therapy, Gene Therapy and Hemopoietic Transplant, IRCCS, Bambino Gesu Pediatric Hospital, Roma, Italy.

Sandeep Kumar Dhanda (SK)

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Maria Luisa Garrè (ML)

Neuro-Oncology Unit, Department of Neurochirurgia, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Corrie E M Gidding (CEM)

Neuro-Oncology Department, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Steffen Hirsch (S)

Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg Health Center, Heidelberg, Germany.

Pauline Hoarau (P)

Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, France.

Mette Jorgensen (M)

Oncology, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.

Christian Kratz (C)

Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.

Lucie Lafay-Cousin (L)

Section of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Angela Mastronuzzi (A)

Pediatric Hematology/Oncology and Stem Cells Transplatation, Bambino Gesu Pediatric Hospital, Roma, Italy.

Lorenza Pastorino (L)

Department of Oncology, Biology and Genetics, University of Genoa, Genoa, Italy.
Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Stefan M Pfister (SM)

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg Health Center, Heidelberg, Germany.
Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany.

Christopher Schroeder (C)

Institute of Medical Genetics and Applied Genomics, University of Tubingen Institute of Human Genetics, Tubingen, Germany.

Miriam Jane Smith (MJ)

Division of Evolution, Infection and Genomics, The University of Manchester, Manchester, UK.

Pia Vahteristo (P)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Department of Medical and Clinical Genetics, Applied Tumor Genomics Research Program, University of Helsinki, Helsinki, Finland.

Roseline Vibert (R)

Department of Genetics, PSL Research University, Institute Curie, Paris, France.

Catheline Vilain (C)

Department of Genetics, Hôpital Universitaire des Enfants Reine Fabiola, ULB Center of Human Genetics, Universite Libre de Bruxelles, Bruxelles, Belgium.
Department of Genetics, Hôpital Erasme, ULB Center of Human Genetics, Universite Libre de Bruxelles, Bruxelles, Belgium.

Nicolas Waespe (N)

CANSEARCH Research Platform, Depatment of pediatric oncology and hematology, University of Geneva, Geneva, Switzerland.
Childhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Ingrid M Winship (IM)

Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

D Gareth Evans (DG)

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester Academic Health Science Centre, School of Biological Sciences,Division of Evolution, Infection and Genomics, The University of Manchester, Manchester, UK.

Laurence Brugieres (L)

Team "Genomics and Oncogenesis of pediatric Brain Tumors"-Paris Saclay University, INSERM U981, VILLEJUIF, France.
Department of Children and Adolescents Oncology, Gustave Roussy Institute, Villejuif, France.

Classifications MeSH