Methylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences.
Journal
NPJ genomic medicine
ISSN: 2056-7944
Titre abrégé: NPJ Genom Med
Pays: England
ID NLM: 101685193
Informations de publication
Date de publication:
29 Jun 2022
29 Jun 2022
Historique:
received:
10
01
2022
accepted:
13
06
2022
entrez:
29
6
2022
pubmed:
30
6
2022
medline:
30
6
2022
Statut:
epublish
Résumé
A growing number of children born are conceived through in vitro fertilisation (IVF), which has been linked to an increased risk of adverse perinatal outcomes, as well as altered growth profiles and cardiometabolic differences in the resultant individuals. Some of these outcomes have also been shown to be influenced by the use of different IVF culture media and this effect is hypothesised to be mediated epigenetically, e.g. through the methylome. As such, we profiled the umbilical cord blood methylome of IVF neonates that underwent preimplantation embryo development in two different IVF culture media (G5 or HTF), using the Infinium Human Methylation EPIC BeadChip. We found no significant methylation differences between the two groups in terms of: (i) systematic differences at CpG sites or regions, (ii) imprinted sites/genes or birth weight-associated sites, (iii) stochastic differences presenting as DNA methylation outliers or differentially variable sites, and (iv) epigenetic gestational age acceleration.
Identifiants
pubmed: 35768464
doi: 10.1038/s41525-022-00310-3
pii: 10.1038/s41525-022-00310-3
pmc: PMC9243125
doi:
Types de publication
Journal Article
Langues
eng
Pagination
39Subventions
Organisme : March of Dimes Foundation (March of Dimes)
ID : 6-FY13-153
Informations de copyright
© 2022. The Author(s).
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