Pharmacokinetics and bioavailability of carprofen in sheep.
bioavailability
carprofen
pharmacokinetics
sheep
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
25
05
2022
received:
16
02
2022
accepted:
19
06
2022
pubmed:
1
7
2022
medline:
11
11
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
The aim of this study was to determine the pharmacokinetics and bioavailability of carprofen in sheep following single intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations of a parenteral formulation at a dose of 4 mg/kg. A total of eight sheep were used for the investigation. The study comprised four periods, according to a crossover design with a 21-day washout period between treatments. Plasma concentrations of carprofen were measured using HPLC-UV. Pharmacokinetic parameters were estimated by non-compartmental model analysis. Following IV administration, t
Substances chimiques
carprofen
FFL0D546HO
Analgesics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-549Subventions
Organisme : The Coordination of Scientific Research Projects, University of Siirt, Turkiye
ID : 2020-SIUVET-039
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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