Successful Treatment of an Adult with Atopic Dermatitis and Lamellar Ichthyosis Using Dupilumab.
biologics
dupilumab
lamellar ichthyosis
Journal
Biologics : targets & therapy
ISSN: 1177-5475
Titre abrégé: Biologics
Pays: New Zealand
ID NLM: 101321511
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
03
2022
accepted:
04
05
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Lamellar ichthyosis (LI) is a rare autosomal cornification disorder, with most cases due to a mutation in the transglutaminase-1 (TGM1) gene on chromosome 14. Patients with LI usually present with a collodion membrane and mild erythroderma at birth, with the collodion membranes shedding within the first weeks of life and being replaced by a generalized scale. Typically, LI is managed with oral retinoids, emollients, and keratolytic agents, eg, lactic acid. We report an LI case associated with atopic dermatitis and asthma that showed a marked improvement with dupilumab treatment. This finding is highly significant as it may represent a breakthrough in the treatment of LI, thus more research is needed to investigate the potential benefits of dupilumab for the treatment of ichthyosis, such as the effects observed in our patient.
Identifiants
pubmed: 35769328
doi: 10.2147/BTT.S362391
pii: 362391
pmc: PMC9236574
doi:
Types de publication
Case Reports
Langues
eng
Pagination
85-88Informations de copyright
© 2022 Binkhonain et al.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare in this work.
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