Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes
brain development
brain disorders
excitatory/inhibitory imbalance
metabotropic glutamate (mGlu) receptor
nervous system
psychiatric disorders
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
03
2022
accepted:
10
05
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Members of the family of metabotropic glutamate receptors are involved in the pathomechanism of several disorders of the nervous system. Besides the well-investigated function of dysfunctional glutamate receptor signaling in neurodegenerative diseases, neurodevelopmental disorders (NDD), like autism spectrum disorders (ASD) and attention-deficit and hyperactivity disorder (ADHD) might also be partly caused by disturbed glutamate signaling during development. However, the underlying mechanism of the type III metabotropic glutamate receptor 8 (mGluR8 or GRM8) involvement in neurodevelopment and disease mechanism is largely unknown. Here we show that the expression pattern of the two orthologs of human
Identifiants
pubmed: 35769333
doi: 10.3389/fnmol.2022.901309
pmc: PMC9234528
doi:
Types de publication
Journal Article
Langues
eng
Pagination
901309Informations de copyright
Copyright © 2022 Lüffe, Bauer, Gioga, Özbay, Romanos, Lillesaar and Drepper.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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