Stress Hyperglycemia Does Not Affect Clinical Outcome of Diabetic Patients Receiving Intravenous Thrombolysis for Acute Ischemic Stroke.
GAR index
acute ischemic stroke
intravenous thrombolysis
outcome
premorbid diabetic status
stress hyperglycemia
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
03
2022
accepted:
06
05
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Although stress hyperglycemia represents a main risk factor for poor outcome among patients with acute ischemic stroke (AIS) undergoing recanalization therapy, we have limited information regarding a possible influence of the premorbid diabetic status on this association. We recruited consecutive patients admitted to the Udine University Hospital with AIS who were treated with intravenous thrombolysis (IVT) from January 2015 to September 2020. On the basis of the premorbid diabetic status, our sample was composed of 130 patients with and 371 patients without diabetes. The glucose-to-glycated hemoglobin ratio (GAR) was used to measure stress hyperglycemia. Patients were stratified into 3 groups by tertiles of GAR (Q1-Q3). The higher GAR index was, the more severe stress hyperglycemia was considered. Among diabetic patients we did not observe any significant association between severe stress hyperglycemia and outcome measures (three-month poor outcome: Q1, 53.7%; Q2, 53.5%; Q3, 58.7%;
Identifiants
pubmed: 35769366
doi: 10.3389/fneur.2022.903987
pmc: PMC9234697
doi:
Types de publication
Journal Article
Langues
eng
Pagination
903987Informations de copyright
Copyright © 2022 Merlino, Pez, Tereshko, Gigli, Lorenzut, Surcinelli and Valente.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
JAMA. 1995 Oct 4;274(13):1017-25
pubmed: 7563451
Transl Stroke Res. 2019 Feb;10(1):78-90
pubmed: 29569040
J Am Heart Assoc. 2018 Apr 12;7(8):
pubmed: 29650712
Eur Neurol. 2016;76(3-4):167-174
pubmed: 27643995
N Engl J Med. 2015 Mar 12;372(11):1009-18
pubmed: 25671797
JAMA. 2019 Jul 23;322(4):326-335
pubmed: 31334795
J Clin Invest. 1997 Sep 1;100(5):1230-9
pubmed: 9276741
Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):151-60
pubmed: 22234163
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
Front Neurol. 2019 Sep 18;10:1003
pubmed: 31620074
J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1668-1673
pubmed: 30890395
AJNR Am J Neuroradiol. 2001 Sep;22(8):1534-42
pubmed: 11559501
Stroke. 2009 Dec;40(12):3804-9
pubmed: 19834016
Stroke. 2013 Mar;44(3):870-947
pubmed: 23370205
Postgrad Med. 2019 Sep;131(7):423-437
pubmed: 31382796
Lancet. 2000 Mar 4;355(9206):773-8
pubmed: 10711923
Neurology. 2002 Sep 10;59(5):669-74
pubmed: 12221155
N Engl J Med. 2001 Nov 8;345(19):1359-67
pubmed: 11794168
J Thromb Thrombolysis. 2021 Apr;51(3):789-797
pubmed: 32830310
N Engl J Med. 2006 Feb 2;354(5):449-61
pubmed: 16452557
Crit Care Med. 2012 Dec;40(12):3180-8
pubmed: 22971590
Crit Care Med. 2010 Apr;38(4):1021-9
pubmed: 20124887
Front Neurol. 2021 Sep 29;12:725002
pubmed: 34659090
Stroke. 2001 Oct;32(10):2426-32
pubmed: 11588337
Ther Adv Neurol Disord. 2021 Sep 22;14:17562864211045876
pubmed: 34589140
Mayo Clin Proc. 2005 Dec;80(12):1558-67
pubmed: 16342648
Crit Care Med. 2011 Jan;39(1):105-11
pubmed: 20975552
N Engl J Med. 1990 Jun 21;322(25):1769-74
pubmed: 2345567
Lancet. 2009 May 23;373(9677):1798-807
pubmed: 19465235
Diabet Med. 1993 Jan-Feb;10(1):27-32
pubmed: 8435984
Semin Thorac Cardiovasc Surg. 2006 Winter;18(4):317-25
pubmed: 17395028
Lancet Neurol. 2007 May;6(5):397-406
pubmed: 17434094
Ann Neurol. 1988 Apr;23(4):416-8
pubmed: 3382181
Crit Care Med. 2008 Aug;36(8):2249-55
pubmed: 18664780
Lancet Neurol. 2012 Mar;11(3):261-71
pubmed: 22341034
Stroke. 2011 May;42(5):1404-11
pubmed: 21454816
Stroke. 2008 Feb;39(2):384-9
pubmed: 18096840
N Engl J Med. 2008 Sep 25;359(13):1317-29
pubmed: 18815396
Stroke. 2019 Dec;50(12):e344-e418
pubmed: 31662037
Crit Care Med. 2013 Jun;41(6):e93-4
pubmed: 23685597
Lancet. 1994 Jan 15;343(8890):155-8
pubmed: 7904009