GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces.
Delivery into the brain
Perivascular spaces
Pharmacopuncture
The Feng Chi point
Journal
Journal of acupuncture and meridian studies
ISSN: 2093-8152
Titre abrégé: J Acupunct Meridian Stud
Pays: Korea (South)
ID NLM: 101490763
Informations de publication
Date de publication:
28 Feb 2022
28 Feb 2022
Historique:
received:
16
08
2021
revised:
10
12
2021
accepted:
30
01
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
2
7
2022
Statut:
ppublish
Résumé
The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood. This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20). These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.
Sections du résumé
Background
UNASSIGNED
The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood.
Results
UNASSIGNED
This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20).
Conclusion
UNASSIGNED
These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.
Identifiants
pubmed: 35770573
pii: j.jams.2022.15.1.43
doi: 10.51507/j.jams.2022.15.1.43
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM