Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity.
aneurysm, dissecting
aorta, thoracic
aortic aneurysm
calcinosis
elastin
sodium fluoride
vascular calcification
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
1
7
2022
medline:
30
7
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established. One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects. Standardized histopathologic scores, immunohistochemistry, and nanoindentation (tissue elastic modulus) were compared with the extent of microcalcification on von Kossa histology and 18F-sodium fluoride autoradiography. Microcalcification content was higher in thoracic aortopathy samples with mild (n=28; 6.17 [2.71-10.39]; Medial microcalcification is a marker of aortopathy, although progression to severe aortopathy is associated with loss of both elastin fibers and microcalcification.
Sections du résumé
BACKGROUND
Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established.
METHODS
One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects. Standardized histopathologic scores, immunohistochemistry, and nanoindentation (tissue elastic modulus) were compared with the extent of microcalcification on von Kossa histology and 18F-sodium fluoride autoradiography.
RESULTS
Microcalcification content was higher in thoracic aortopathy samples with mild (n=28; 6.17 [2.71-10.39];
CONCLUSIONS
Medial microcalcification is a marker of aortopathy, although progression to severe aortopathy is associated with loss of both elastin fibers and microcalcification.
Identifiants
pubmed: 35770666
doi: 10.1161/ATVBAHA.122.317111
pmc: PMC9311465
doi:
Substances chimiques
Sodium Fluoride
8ZYQ1474W7
Elastin
9007-58-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1048-1059Subventions
Organisme : British Heart Foundation
ID : RG/16/10/32375
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221295/Z/20/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/34/34354
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/31/33676
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/61/29877
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/09/002
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/09/002/26360
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT103782AIA
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/107/32681
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/15/34155
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/83/33370
Pays : United Kingdom
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