The many roles of dystroglycan in nervous system development and function: Dystroglycan and neural circuit development: Dystroglycan and neural circuit development.
axon guidance
dystroglycan
neural migration
synapse formation
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
21
06
2022
received:
09
05
2022
accepted:
22
06
2022
pubmed:
1
7
2022
medline:
4
1
2023
entrez:
30
6
2022
Statut:
ppublish
Résumé
The glycoprotein dystroglycan was first identified in muscle, where it functions as part of the dystrophin glycoprotein complex to connect the extracellular matrix to the actin cytoskeleton. Mutations in genes involved in the glycosylation of dystroglycan cause a form of congenital muscular dystrophy termed dystroglycanopathy. In addition to its well-defined role in regulating muscle integrity, dystroglycan is essential for proper central and peripheral nervous system development. Patients with dystroglycanopathy can present with a wide range of neurological perturbations, but unraveling the complex role of Dag1 in the nervous system has proven to be a challenge. Over the past two decades, animal models of dystroglycanopathy have been an invaluable resource that has allowed researchers to elucidate dystroglycan's many roles in neural circuit development. In this review, we summarize the pathways involved in dystroglycan's glycosylation and its known interacting proteins, and discuss how it regulates neuronal migration, axon guidance, synapse formation, and its role in non-neuronal cells.
Substances chimiques
Dystroglycans
146888-27-9
Glycoproteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-80Subventions
Organisme : NINDS NIH HHS
ID : F31 NS120649
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091027
Pays : United States
Informations de copyright
© 2022 American Association for Anatomy.
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