Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
M3R
RNAscope
clearing
lightsheet
melanocortin
sex differences
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
24
05
2022
received:
15
02
2022
accepted:
27
05
2022
pubmed:
1
7
2022
medline:
17
9
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
The central melanocortin system is fundamentally important for controlling food intake and energy homeostasis. Melanocortin-3 receptor (MC3R) is one of two major receptors of the melanocortin system found in the brain. In contrast to the well-characterized melanocortin-4 receptor (MC4R), little is known regarding the organization of MC3R-expressing neural circuits. To increase our understanding of the intrinsic organization of MC3R neural circuits, identify specific differences between males and females, and gain a neural systems level perspective of this circuitry, we conducted a brain-wide mapping of neurons labeled for MC3R and characterized the distribution of their projections. Analysis revealed MC3R neuronal and terminal labeling in multiple brain regions that control a diverse range of physiological functions and behavioral processes. Notably, dense labeling was observed in the hypothalamus, as well as areas that share considerable connections with the hypothalamus, including the cortex, amygdala, thalamus, and brainstem. Additionally, MC3R neuronal labeling was sexually dimorphic in several areas, including the anteroventral periventricular area, arcuate nucleus, principal nucleus of the bed nucleus of the stria terminalis, and ventral premammillary region. Altogether, anatomical evidence reported here suggests that MC3R has the potential to influence several different classes of motivated behavior that are essential for survival, including ingestive, reproductive, defensive, and arousal behaviors, and is likely to modulate these behaviors differently in males and females.
Identifiants
pubmed: 35770983
doi: 10.1002/cne.25379
pmc: PMC9724692
mid: NIHMS1811668
doi:
Substances chimiques
Mc3r protein, mouse
0
Melanocortins
0
Receptor, Melanocortin, Type 3
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2835-2851Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK123879
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK127065
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106476
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126715
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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