Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes.


Journal

Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343

Informations de publication

Date de publication:
11 2022
Historique:
pubmed: 1 7 2022
medline: 26 10 2022
entrez: 30 6 2022
Statut: ppublish

Résumé

Dental care-related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. Therefore, we performed a genome-wide association study to identify genetic variants contributing to DFA. Adult and adolescent participants were from 4 cohorts (3 from the US-based Center for Oral Health Research in Appalachia,

Identifiants

pubmed: 35771046
doi: 10.1177/00220345221105226
pmc: PMC9608092
doi:

Substances chimiques

Neurotensin 39379-15-2

Types de publication

Meta-Analysis Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1526-1536

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL089292
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE014899
Pays : United States
Organisme : NIOSH CDC HHS
ID : R01 OH009878
Pays : United States
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : U01 DE018903
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202802/Z/16/Z
Pays : United Kingdom

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Auteurs

Y Zhou (Y)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

D W McNeil (DW)

Department of Psychology, West Virginia University, Morgantown, WV, USA.
Department of Dental Public Health and Professional Practice, School of Dentistry, West Virginia University, Morgantown, WV, USA.

S Haworth (S)

Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, Bristol, UK.
Bristol Dental School, University of Bristol, Bristol, UK.

T Dudding (T)

Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, Bristol, UK.
Bristol Dental School, University of Bristol, Bristol, UK.

J M Chernus (JM)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

C Liu (C)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

D Liu (D)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

C D Wright (CD)

Department of Psychology, West Virginia University, Morgantown, WV, USA.

J Brumbaugh (J)

Department of Psychology, West Virginia University, Morgantown, WV, USA.

C L Randall (CL)

Department of Oral Health Sciences, University of Washington School of Dentistry, Seattle, WA, USA.

R J Weyant (RJ)

Department of Dental Public Health, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

R J Crout (RJ)

Department of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV, USA.

B Foxman (B)

Center for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

S Reis (S)

The Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.

N J Timpson (NJ)

Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, Bristol, UK.
Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK.

M L Marazita (ML)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
The Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

J R Shaffer (JR)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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