The effect of muscle length on post-tetanic potentiation of C57BL/6 and skMLCK
Muscle length
Myosin
Potentiation
Regulatory light chain
Journal
Journal of muscle research and cell motility
ISSN: 1573-2657
Titre abrégé: J Muscle Res Cell Motil
Pays: Netherlands
ID NLM: 8006298
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
17
03
2022
accepted:
12
05
2022
pubmed:
1
7
2022
medline:
31
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
Post-tetanic potentiation of fast-twitch skeletal muscle is dependent on muscle length, with greater potentiation observed at shorter compared to longer lengths. The structural effects of the primary potentiation mechanism, phosphorylation of the regulatory light chain (RLC) of myosin, are thought to explain this relationship. The purpose of these experiments was to determine whether the length-dependence of potentiation would be attenuated in the absence of RLC phosphorylation. To this end, we compared isometric twitch potentiation of mouse extensor digitorum longus (EDL) muscles with (wildtype, WT) and without (skeletal myosin light chain kinase knockout, skMLCK
Identifiants
pubmed: 35771335
doi: 10.1007/s10974-022-09620-6
pii: 10.1007/s10974-022-09620-6
doi:
Substances chimiques
Myosins
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-111Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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