Structure-Based Design, Optimization, and Development of [

Animals Brain / diagnostic imaging Fluorine Radioisotopes Ligands Positron-Emission Tomography / methods Protein Binding Rats Receptor, Cannabinoid, CB2 / metabolism Receptors, Cannabinoid / metabolism

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 07 2022
Historique:
pubmed: 1 7 2022
medline: 16 7 2022
entrez: 30 6 2022
Statut: ppublish

Résumé

The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy of neurodegenerative diseases and cancer. In this study, we aimed at the development of a novel

Identifiants

DOI: 10.1021/acs.jmedchem.2c00256 PMID: 35771668
pubmed: 35771668
doi: 10.1021/acs.jmedchem.2c00256
doi:

Substances chimiques

Fluorine Radioisotopes 0
Ligands 0
Receptor, Cannabinoid, CB2 0
Receptors, Cannabinoid 0
Fluorine-18 GZ5I74KB8G

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9034-9049

Auteurs

Daniel Gündel (D)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Winnie Deuther-Conrad (W)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Lea Ueberham (L)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Sarandeep Kaur (S)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Elina Otikova (E)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Rodrigo Teodoro (R)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Magali Toussaint (M)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Thu Hang Lai (TH)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.
Department of Research and Development, ROTOP Pharmaka GmbH, 01069 Dresden, Germany.
ORCID: 0000-0001-8157-8979

Oliver Clauß (O)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.
ORCID: 0000-0001-5067-4845

Matthias Scheunemann (M)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Guy Bormans (G)

Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, BE-3000 Leuven, Belgium.
ORCID: 0000-0002-0335-7190

Michael Bachmann (M)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.

Klaus Kopka (K)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.
Faculty of Chemistry and Food Chemistry, School of Science, TU Dresden, 01069 Dresden, Germany.

Peter Brust (P)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.
The Lübeck Institute of Experimental Dermatology, University Medical Center Schleswig-Holstein, 23562 Lübeck, Germany.
ORCID: 0000-0001-5555-7058

Rareş-Petru Moldovan (RP)

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany.
ORCID: 0000-0003-3119-7945

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB2 › Structure-Based Design, Optimization, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Structure-Based Design, Optimization, and...