Characteristic patterns of SARS-CoV-2 on chest CT suggests a hematologic pathway for viral entry into the lung.
COVID-19
Chest CT
Vascular endothelium
Journal
Clinical imaging
ISSN: 1873-4499
Titre abrégé: Clin Imaging
Pays: United States
ID NLM: 8911831
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
17
01
2022
revised:
14
06
2022
accepted:
19
06
2022
pubmed:
1
7
2022
medline:
17
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
Many SARS-CoV-2 studies have supported the theory that the Type II alveolar epithelial cells (AEC-2) are the primary portal of entry of the virus into the lung following its brief nasal occupation. However, the theory of inhalational transmission of the virus from the ciliated and goblet nasal cells to the lung parenchyma is not supported by the imaging findings on chest computerized tomography (CT), leading the authors to consider an alternative pathway from the nose to the lung parenchyma that could explain the peripheral, basilar predominant pattern of early disease. Imaging supports that the pulmonary capillaries may be an important vehicle for transmission of the virus and/or associated inflammatory mediators to the lung epithelium.
Identifiants
pubmed: 35772334
pii: S0899-7071(22)00167-X
doi: 10.1016/j.clinimag.2022.06.011
pmc: PMC9233344
pii:
doi:
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-94Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
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