GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
03
05
2021
accepted:
22
06
2022
pubmed:
1
7
2022
medline:
20
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between target nucleotides t10 and t11. In animals, the PIWI proteins-a specialized class of Argonaute proteins-use 21-35 nucleotide PIWI-interacting RNAs (piRNAs) to direct transposon silencing, protect the germline genome, and regulate gene expression during gametogenesis
Identifiants
pubmed: 35772669
doi: 10.1038/s41586-022-05009-0
pii: 10.1038/s41586-022-05009-0
pmc: PMC9385479
doi:
Substances chimiques
Argonaute Proteins
0
Cue110 protein, mouse
0
Intracellular Signaling Peptides and Proteins
0
RNA, Small Interfering
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
618-625Subventions
Organisme : NIGMS NIH HHS
ID : R37 GM062862
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136275
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127090
Pays : United States
Informations de copyright
© 2022. The Author(s).
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