Alterations of Microstructure and Sodium Homeostasis in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI and Sodium MRI Study.

Amyotrophic Lateral Sclerosis / diagnostic imaging Anisotropy Brain / diagnostic imaging Diffusion Tensor Imaging / methods Homeostasis Humans Magnetic Resonance Imaging / methods Pyramidal Tracts Sodium

Journal

AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708

Informations de publication

Date de publication:
07 2022
Historique:
received: 06 01 2022
accepted: 10 05 2022
pubmed: 1 7 2022
medline: 12 7 2022
entrez: 30 6 2022
Statut: ppublish

Résumé

While conventional MR imaging has limited value in amyotrophic lateral sclerosis, nonconventional MR imaging has shown alterations of microstructure using diffusion MR imaging and recently sodium homeostasis with sodium MR imaging. We aimed to investigate the topography of brain regions showing combined microstructural and sodium homeostasis alterations in amyotrophic lateral sclerosis subgroups according to their disease-progression rates. Twenty-nine patients with amyotrophic lateral sclerosis and 24 age-matched healthy controls were recruited. Clinical assessments included disease duration and the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale. Patients were clinically differentiated into fast ( Patients with amyotrophic lateral sclerosis showed significantly higher sodium concentrations and lower fractional anisotropy, along with higher sodium concentrations and higher mean diffusivity compared with healthy controls, primarily within the corticospinal tracts, corona radiata, and body and genu of the corpus callosum. Fast progressors showed wider-spread abnormalities mainly in the frontal areas. In slow progressors, only fractional anisotropy measures showed abnormalities compared with healthy controls, localized in focal regions of the corticospinal tracts, the body of corpus callosum, corona radiata, and thalamic radiation. The present study evidenced widespread combined microstructural and sodium homeostasis brain alterations in fast amyotrophic lateral sclerosis progressors.

Sections du résumé

BACKGROUND AND PURPOSE
While conventional MR imaging has limited value in amyotrophic lateral sclerosis, nonconventional MR imaging has shown alterations of microstructure using diffusion MR imaging and recently sodium homeostasis with sodium MR imaging. We aimed to investigate the topography of brain regions showing combined microstructural and sodium homeostasis alterations in amyotrophic lateral sclerosis subgroups according to their disease-progression rates.
MATERIALS AND METHODS
Twenty-nine patients with amyotrophic lateral sclerosis and 24 age-matched healthy controls were recruited. Clinical assessments included disease duration and the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale. Patients were clinically differentiated into fast (
RESULTS
Patients with amyotrophic lateral sclerosis showed significantly higher sodium concentrations and lower fractional anisotropy, along with higher sodium concentrations and higher mean diffusivity compared with healthy controls, primarily within the corticospinal tracts, corona radiata, and body and genu of the corpus callosum. Fast progressors showed wider-spread abnormalities mainly in the frontal areas. In slow progressors, only fractional anisotropy measures showed abnormalities compared with healthy controls, localized in focal regions of the corticospinal tracts, the body of corpus callosum, corona radiata, and thalamic radiation.
CONCLUSIONS
The present study evidenced widespread combined microstructural and sodium homeostasis brain alterations in fast amyotrophic lateral sclerosis progressors.

Identifiants

DOI: 10.3174/ajnr.A7559 PMID: 35772800 PMC: PMC9262065
pubmed: 35772800
pii: ajnr.A7559
doi: 10.3174/ajnr.A7559
pmc: PMC9262065
doi:

Substances chimiques

Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

984-990

Informations de copyright

© 2022 by American Journal of Neuroradiology.

Références

Front Neurol. 2019 Feb 11;10:84
pubmed: 30804885
Ann Neurol. 2013 Jul;74(1):20-38
pubmed: 23686809
Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct - Nov;17(7-8):561-570
pubmed: 27087114
Front Neuroinform. 2014 Apr 28;8:44
pubmed: 24817849
Int J Epidemiol. 2017 Feb 1;46(1):57-74
pubmed: 27185810
J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):628-32
pubmed: 26152368
Can J Neurol Sci. 2014 Jan;41(1):53-7
pubmed: 24384338
Neuroimage Clin. 2018 Apr 04;19:122-129
pubmed: 30035009
Neurology. 2010 Nov 2;75(18):1645-52
pubmed: 21041787
Ann Neurol. 2003 Feb;53(2):174-80
pubmed: 12557283
Neurology. 2019 Sep 3;93(10):e984-e994
pubmed: 31409738
Neuroimage. 2017 Aug 15;157:173-183
pubmed: 28602596
Brain. 2004 Feb;127(Pt 2):340-50
pubmed: 14607785
J Neurol Sci. 1999 Oct 31;169(1-2):13-21
pubmed: 10540002
J Neurol Sci. 2008 Dec 15;275(1-2):69-73
pubmed: 18721928
Neuroimage Clin. 2017 Oct 14;17:145-152
pubmed: 29071208
PLoS One. 2013 Sep 03;8(9):e73021
pubmed: 24019889
Magn Reson Med. 2009 Dec;62(6):1565-73
pubmed: 19859915
Neurology. 2006 Jan 24;66(2):265-7
pubmed: 16434671
Radiology. 2019 Aug;292(2):422-428
pubmed: 31184559
Hum Brain Mapp. 2021 Feb 15;42(3):737-752
pubmed: 33103324
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Muscle Nerve. 2021 Sep;64(3):346-351
pubmed: 34076262
Neuroepidemiology. 2013;41(2):118-30
pubmed: 23860588
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Ann Neurol. 2020 May;87(5):725-738
pubmed: 32072667
Lancet Neurol. 2005 Apr;4(4):229-38
pubmed: 15778102
Ann Neurol. 2014 Feb;75(2):287-97
pubmed: 24382602
Brain. 2020 Dec 1;143(12):3603-3618
pubmed: 33439988
Neuroimage Clin. 2020;27:102315
pubmed: 32593977
Expert Rev Neurother. 2020 Mar;20(3):237-249
pubmed: 31937156
J Neurol Sci. 2016 Aug 15;367:177-83
pubmed: 27423585
Acta Neuropathol. 2018 Apr;135(4):489-509
pubmed: 29549424
Front Neurol. 2019 Mar 05;10:193
pubmed: 30891004
J Magn Reson Imaging. 2014 Mar;39(3):641-7
pubmed: 23843179
Med Genet. 2018;30(2):252-258
pubmed: 30220791
BMC Neurol. 2017 Apr 17;17(1):73
pubmed: 28412941
J Neurosci. 1992 Feb;12(2):430-9
pubmed: 1311030
J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):740-6
pubmed: 21402743
Neuroimage Clin. 2021;30:102674
pubmed: 33901988

Auteurs

M M El Mendili (MM)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France mm.elmendili@univ-amu.fr.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0002-4020-0926

A-M Grapperon (AM)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
APHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France.
ORCID: 0000-0002-4196-9374

R Dintrich (R)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
APHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France.
ORCID: 0000-0003-1117-9061

J-P Stellmann (JP)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0003-2565-2833

J-P Ranjeva (JP)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0001-8073-102X

M Guye (M)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0002-4435-2257

A Verschueren (A)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0003-1266-9062

S Attarian (S)

APHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France.
ORCID: 0000-0002-7211-4694

W Zaaraoui (W)

From the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France.
APHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France.
ORCID: 0000-0002-9036-6246

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Phénomènes chimiques › Anisotropie › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Voies efférentes › Tractus pyramidaux › Alterations of Microstructure and Sodium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Alterations of Microstructure and Sodium...