Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and Ca
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
29 Jun 2022
29 Jun 2022
Historique:
received:
21
05
2021
revised:
02
06
2022
accepted:
22
06
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
1
7
2022
Statut:
aheadofprint
Résumé
Chemotherapy-induced peripheral neuropathy (CIPN) affects about 68% of patients undergoing chemotherapy, causing debilitating neuropathic pain and reducing quality of life. Cisplatin is a commonly used platinum-based chemotherapeutic drug known to cause CIPN, possibly by causing oxidative stress damage to primary sensory neurons. Metabotropic glutamate receptors (mGluRs) are widely hypothesized to be involved in pain processing and pain mitigation. Meclizine is an H1 histamine receptor antagonist known to have neuroprotective effects, including an anti-oxidative effect. Here, we used a mouse model of cisplatin-induced CIPN using male and female mice to test agonists of mGluR8 and group II mGluR as well as meclizine as interventions to reduce cisplatin-induced pain. We performed behavioral pain tests, and we imaged Ca
Identifiants
pubmed: 35772967
pii: JNEUROSCI.1064-21.2022
doi: 10.1523/JNEUROSCI.1064-21.2022
pmc: PMC9351649
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026677
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE031477
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
Déclaration de conflit d'intérêts
Authors declare no conflicts of interest and no financial conflicts.
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