Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors.
Journal
Behavioural neurology
ISSN: 1875-8584
Titre abrégé: Behav Neurol
Pays: Netherlands
ID NLM: 8914585
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
02
2022
accepted:
05
06
2022
entrez:
1
7
2022
pubmed:
2
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
The glucagon-like peptide 1 (GLP-1) is a hormone which is produced in the enteroendocrine L-cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in the brain which has numerous metabolic effects. The central GLP-1R's role in cognitive functioning is well known. On the contrary, it has been shown that exercise has positive effects on brain function. So, we decided to elucidate whether the central GLP-1 has a role in memory and learning. Thirty-two rats were used in this experiment in 4 groups. After anesthetizing the rats, the right lateral ventricle was detected, and a cannula was directed to the ventricle. Ten micrograms of exendin-3 or sterile saline, according to the group, was injected via ICV once daily for seven days. The rats in the exercise group considered an exercise period of one hour each day (17 meters per minute) for seven consecutive days. To evaluate the performance of memory and learning, a standard Morris water maze (MWM) tank was utilized. According to the results, the TE-exendin group showed a statistically significant difference from the TE-SAL group in both parameters of latency and time in the zone. In summary, memory and learning were improved by GLP-1R in the exercise group, but not in the sedentary group, which we can hypothesize that exercise can affect memory and learning through this pathway.
Identifiants
pubmed: 35774081
doi: 10.1155/2022/2900628
pmc: PMC9239811
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2900628Informations de copyright
Copyright © 2022 Majid Taati et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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