Conserved meningeal lymphatic drainage circuits in mice and humans.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
received:
05
01
2022
revised:
07
04
2022
accepted:
08
06
2022
entrez:
1
7
2022
pubmed:
2
7
2022
medline:
8
7
2022
Statut:
ppublish
Résumé
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained unclear. Here, we used light-sheet fluorescence microscopy (LSFM) imaging of mouse whole-head preparations after OVA-A555 tracer injection into the cerebrospinal fluid (CSF) and performed real-time vessel-wall (VW) magnetic resonance imaging (VW-MRI) after systemic injection of gadobutrol in patients with neurological pathologies. We observed a conserved three-dimensional anatomy of MLVs in mice and humans that aligned with dural venous sinuses but not with nasal CSF outflow, and we discovered an extended anterior MLV network around the cavernous sinus, with exit routes through the foramina of emissary veins. VW-MRI may provide a diagnostic tool for patients with CSF drainage defects and neurological diseases.
Identifiants
pubmed: 35776089
pii: 213319
doi: 10.1084/jem.20220035
pmc: PMC9253621
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BrainWash
ID : ANR-17-CE14-0005
Organisme : Lymbrain
ID : ANR-20-CE16-0027-01
Organisme : Venolymphatic
ID : BBT.1300
Organisme : Programme Capes Cofecub 2021
ID : 44999PG
Organisme : European Research Council
ID : 834161
Pays : International
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : CIHU-2021
Organisme : European Society of Cardiology
Organisme : Investissements d'Avenir
ID : ANR-11-INBS-0006
Organisme : Paris Institute of Neurosciences-Institut Hospitalo Universitaire
ID : IAIHU-06
Organisme : Fondation pour la Recherche Médicale
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 Jacob et al.
Références
Nat Commun. 2022 Jan 11;13(1):203
pubmed: 35017525
World Neurosurg. 2019 Sep;129:190-199
pubmed: 31136838
Cerebrospinal Fluid Res. 2005 Sep 20;2:6
pubmed: 16174293
Elife. 2017 Oct 03;6:
pubmed: 28971799
JCI Insight. 2021 Aug 9;6(15):
pubmed: 34156985
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):
pubmed: 33446503
Nat Commun. 2017 Nov 10;8(1):1434
pubmed: 29127332
Cell. 2014 Nov 6;159(4):896-910
pubmed: 25417164
Genes Dev. 2011 Apr 15;25(8):831-44
pubmed: 21498572
Nat Neurosci. 2018 Oct;21(10):1380-1391
pubmed: 30224810
Nat Med. 2021 Mar;27(3):411-418
pubmed: 33462448
Nat Commun. 2019 Jan 16;10(1):229
pubmed: 30651548
Nat Commun. 2019 Oct 9;10(1):4594
pubmed: 31597914
Brain. 2022 May 24;145(4):1464-1472
pubmed: 34849609
JAMA Netw Open. 2020 Jul 1;3(7):e2011625
pubmed: 32706384
Magn Reson Med. 2020 Dec;84(6):3256-3270
pubmed: 32621291
Nat Neurosci. 2022 May;25(5):555-560
pubmed: 35301477
Nature. 2020 Jan;577(7792):689-694
pubmed: 31942068
J Clin Invest. 2021 Aug 16;131(16):
pubmed: 34181595
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
Acta Neuropathol. 2016 Sep;132(3):317-38
pubmed: 27522506
J Neurosci. 2021 Sep 15;41(37):7698-7711
pubmed: 34526407
Elife. 2019 May 07;8:
pubmed: 31063132
Cell. 2021 Feb 18;184(4):1000-1016.e27
pubmed: 33508229
Stroke. 2022 Mar;53(3):987-998
pubmed: 35144488
Nat Rev Neurol. 2015 Aug;11(8):457-70
pubmed: 26195256
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
Nat Neurosci. 2019 Feb;22(2):317-327
pubmed: 30598527
Cell Res. 2020 Mar;30(3):229-243
pubmed: 32094452
J Clin Med. 2020 Oct 19;9(10):
pubmed: 33086702
Nature. 2015 Jul 16;523(7560):337-41
pubmed: 26030524
Nat Commun. 2020 Jan 17;11(1):354
pubmed: 31953399
J Bone Joint Surg Am. 1955 Oct;37-A(5):985-1004
pubmed: 13263344
Nat Commun. 2021 Oct 28;12(1):6219
pubmed: 34711819
Nat Commun. 2019 Nov 22;10(1):5306
pubmed: 31757960
J Neurosurg. 1983 Sep;59(3):369-83
pubmed: 6886750
J Vis Exp. 2020 May 22;(159):
pubmed: 32510513
Nat Commun. 2020 Sep 10;11(1):4524
pubmed: 32913280
Nature. 2018 Aug;560(7717):185-191
pubmed: 30046111
J Exp Med. 2019 Nov 4;216(11):2492-2502
pubmed: 31455602
Cell Mol Life Sci. 2021 Mar;78(6):2429-2457
pubmed: 33427948
Sci Rep. 2018 May 8;8(1):7194
pubmed: 29740121
Nat Neurosci. 2022 May;25(5):567-576
pubmed: 35501382
Nature. 2019 Aug;572(7767):62-66
pubmed: 31341278
Nature. 2021 May;593(7858):255-260
pubmed: 33911285
JCI Insight. 2022 Feb 8;7(3):
pubmed: 34905509
Bone. 2014 Jun;63:47-52
pubmed: 24583233
Nat Neurosci. 2018 Sep;21(9):1209-1217
pubmed: 30150661
J Exp Med. 2017 Dec 4;214(12):3645-3667
pubmed: 29141865
Neuron. 2016 Sep 7;91(5):957-973
pubmed: 27608759
J Exp Med. 2015 Jun 29;212(7):991-9
pubmed: 26077718