Current concepts and perspectives for articular cartilage regeneration.

Cartilage regeneration Growth factors Osteochondral defects bioprinting Scaffolds Tissue engineering

Journal

Journal of experimental orthopaedics

ISSN: 2197-1153

Titre abrégé: J Exp Orthop

Pays: Germany

ID NLM: 101653750

Informations de publication

Date de publication:
01 Jul 2022

Historique:

received: 30 03 2022

accepted: 13 06 2022

entrez: 1 7 2022

pubmed: 2 7 2022

medline: 2 7 2022

Statut: epublish

Résumé

Articular cartilage injuries are common in the population. The increment in the elderly people and active life results in an increasing demand for new technologies and good outcomes to satisfy longer and healthier life expectancies. However, because of cartilage's low regenerative capacity, finding an efficacious treatment is still challenging for orthopedics.Since the pioneering studies based on autologous cell transplantation, regenerative medicine has opened new approaches for cartilage lesion treatment.Tissue engineering combines cells, biomaterials, and biological factors to regenerate damaged tissues, overcoming conventional therapeutic strategies. Cells synthesize matrix structural components, maintain tissue homeostasis by modulating metabolic, inflammatory, and immunologic pathways. Scaffolds are well acknowledged by clinicians in regenerative applications since they provide the appropriate environment for cells, can be easily implanted, reduce surgical morbidity, allow enhanced cell proliferation, maturation, and an efficient and complete integration with surrounding articular cartilage. Growth factors are molecules that facilitate tissue healing and regeneration by stimulating cell signal pathways.To date, different cell sources and a wide range of natural and synthetic scaffolds have been used both in pre-clinical and clinical studies with the aim to find the suitable solution for recapitulating cartilage microenvironment and inducing the formation of a new tissue with the biochemical and mechanical properties of the native one. Here, we describe the current concepts for articular cartilage regeneration, highlighting the key actors of this process trying to identify the best perspectives.

Identifiants

DOI: 10.1186/s40634-022-00498-4 PMID: 35776217 PMC: PMC9249961

pubmed: 35776217

doi: 10.1186/s40634-022-00498-4

pii: 10.1186/s40634-022-00498-4

pmc: PMC9249961

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

Subventions

Organisme : Ministero della Salute

ID : 5x1000 2019 (redditi 2018).

Informations de copyright

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