The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
12
2021
accepted:
03
05
2022
entrez:
1
7
2022
pubmed:
2
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneuploidy per se is sufficient to drive CIN, however due to limited models and heterogenous results, it has remained controversial which aspects of aneuploidy can drive CIN. In this study we systematically tested the impact of different types of aneuploidies on the induction of CIN. We generated a plethora of isogenic aneuploid clones harboring whole chromosome or segmental aneuploidies in human p53-deficient RPE-1 cells. We observed increased segregation errors in cells harboring trisomies that strongly correlated to the number of gained genes. Strikingly, we found that clones harboring only monosomies do not induce a CIN phenotype. Finally, we found that an initial chromosome breakage event and subsequent fusion can instigate breakage-fusion-bridge cycles. By investigating the impact of monosomies, trisomies and segmental aneuploidies on chromosomal instability we further deciphered the complex relationship between aneuploidy and CIN.
Identifiants
pubmed: 35776704
doi: 10.1371/journal.pone.0268579
pii: PONE-D-21-40038
pmc: PMC9249180
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0268579Déclaration de conflit d'intérêts
No, there is no conflict of interest. My manuscript contains the following statement: "The authors declare that they have no conflict of interest."
Références
Cancer Cell. 2007 Jan;11(1):25-36
pubmed: 17189716
Science. 2006 Jul 21;313(5785):367-70
pubmed: 16857942
Nature. 2010 Nov 11;468(7321):321-5
pubmed: 20962780
EMBO J. 1995 Jun 1;14(11):2580-8
pubmed: 7781611
Mol Syst Biol. 2012;8:608
pubmed: 22968442
Elife. 2014 Jul 29;3:e03023
pubmed: 25073701
Nature. 1998 Dec 17;396(6712):643-9
pubmed: 9872311
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13692-7
pubmed: 9811862
EMBO J. 2000 Nov 1;19(21):5720-8
pubmed: 11060023
Genes Dev. 2019 Aug 1;33(15-16):1031-1047
pubmed: 31196865
Nat Commun. 2019 Aug 8;10(1):3585
pubmed: 31395887
Genes Chromosomes Cancer. 2000 May;28(1):92-7
pubmed: 10738307
Cell Rep. 2016 Nov 8;17(7):1755-1763
pubmed: 27829147
Genome Biol. 2016 May 31;17(1):115
pubmed: 27246460
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12644-9
pubmed: 22802626
Cell. 2011 Feb 18;144(4):499-512
pubmed: 21315436
EMBO Rep. 2021 Dec 6;22(12):e52509
pubmed: 34698427
Nat Rev Mol Cell Biol. 2015 Aug;16(8):473-85
pubmed: 26204159
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):303-8
pubmed: 10618413
Nature. 2008 Jul 24;454(7203):455-62
pubmed: 18650916
BMC Genomics. 2014 Feb 18;15:139
pubmed: 24548329
PLoS Genet. 2013;9(1):e1003232
pubmed: 23358723
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11866-11871
pubmed: 31142641
Autophagy. 2013 Feb 1;9(2):246-8
pubmed: 23108329
Cancer Cell. 2018 Apr 9;33(4):676-689.e3
pubmed: 29622463
Cancer Res. 2011 May 15;71(10):3447-52
pubmed: 21270108
Cell. 2010 Oct 1;143(1):71-83
pubmed: 20850176
Cell. 2018 Sep 6;174(6):1347-1360
pubmed: 30193109
Nat Rev Genet. 2020 Jan;21(1):44-62
pubmed: 31548659
Nature. 1997 Apr 10;386(6625):623-7
pubmed: 9121588
Genome Biol. 2016 May 31;17(1):116
pubmed: 27246599
Cell Rep. 2017 Jun 20;19(12):2423-2431
pubmed: 28636931
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6
pubmed: 19458043
Nature. 2017 Aug 24;548(7668):461-465
pubmed: 28738408
Cold Spring Harb Perspect Med. 2017 Jan 3;7(1):
pubmed: 28049655
Science. 2008 Oct 31;322(5902):703-9
pubmed: 18974345
Trends Genet. 2011 Nov;27(11):446-53
pubmed: 21872963
Genome Res. 2014 Dec;24(12):2022-32
pubmed: 25236618
Trends Genet. 2019 Apr;35(4):279-291
pubmed: 30745166
Bioessays. 2012 Oct;34(10):893-900
pubmed: 22926916
Science. 2020 Apr 17;368(6488):
pubmed: 32299917
Elife. 2015 May 05;4:
pubmed: 25942454
Science. 2011 Sep 30;333(6051):1895-8
pubmed: 21960636
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21010-5
pubmed: 23197825
Nat Commun. 2021 Sep 22;12(1):5576
pubmed: 34552071
Dev Cell. 2021 Sep 13;56(17):2427-2439.e4
pubmed: 34352222
J Comput Biol. 2012 Jun;19(6):662-78
pubmed: 22506505
Recent Results Cancer Res. 2015;200:95-113
pubmed: 26376874
PLoS Genet. 2012;8(5):e1002719
pubmed: 22615582
Dev Cell. 2017 Jun 19;41(6):638-651.e5
pubmed: 28633018
Epigenomics. 2019 Dec;11(16):1827-1837
pubmed: 31755744
Nat Commun. 2017 Oct 31;8(1):1212
pubmed: 29089484
Mol Biol Cell. 2004 Mar;15(3):1101-11
pubmed: 14699058
Dev Cell. 2018 Feb 26;44(4):420-431
pubmed: 29486194
EMBO Rep. 2021 Aug 4;22(8):e52032
pubmed: 34105235
Dev Cell. 2021 Sep 13;56(17):2440-2454.e6
pubmed: 34352223
Genes Dev. 2015 Oct 1;29(19):2010-21
pubmed: 26404941
Genome Res. 2022 Jun 14;:
pubmed: 35701073
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17031-17040
pubmed: 32632008
Sci Rep. 2016 Mar 09;6:22828
pubmed: 26956415
Genome Res. 2013 Feb;23(2):300-11
pubmed: 23275495
J Cell Biol. 2010 Feb 8;188(3):369-81
pubmed: 20123995
Genetics. 2008 Jun;179(2):737-46
pubmed: 18558649
Science. 2007 Aug 17;317(5840):916-24
pubmed: 17702937
Nat Protoc. 2006;1(1):264-75
pubmed: 17406243
Science. 2011 Aug 19;333(6045):1026-30
pubmed: 21852501
Trends Cancer. 2016 Oct;2(10):561-571
pubmed: 28741487
Nature. 2015 Jun 11;522(7555):179-84
pubmed: 26017310
Nat Commun. 2016 Feb 15;7:10754
pubmed: 26876972
Curr Biol. 2010 Mar 23;20(6):R285-95
pubmed: 20334839
Nature. 2017 Oct 19;550(7676):402-406
pubmed: 28976970
Bioinformatics. 2007 Apr 1;23(7):892-4
pubmed: 17267432
Nat Commun. 2020 Mar 20;11(1):1501
pubmed: 32198375