Exosomes in urological diseases - Biological functions and clinical applications.
Biomarker
Exosome
Extracellular vesicle
Urological benign disease
Urological malignancy
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
28 09 2022
28 09 2022
Historique:
received:
30
04
2022
revised:
22
06
2022
accepted:
23
06
2022
pubmed:
2
7
2022
medline:
10
8
2022
entrez:
1
7
2022
Statut:
ppublish
Résumé
Exosomes are extracellular vesicles with a variety of biological functions that exist in various biological body fluids and exert their functions through proteins, nucleic acids, lipids, and metabolites. Recent discoveries have revealed the functional and biomarker roles of miRNAs in urological diseases, including benign diseases and malignancies. Exosomes have several uses in the diagnosis, treatment, and monitoring of urological diseases, especially cancer. Proteins and nucleic acids can be used as alternative biomarkers for detecting urological diseases. Additionally, exosomes can be detected in most body fluids, thereby avoiding pathogenesis. More importantly, for urological tumors, exosomes display a higher sensitivity than circulating tumor cells and tumor-derived DNA in body fluid biopsies because of their low immunogenicity and high stability. These advantages have made it a research hotspot in recent years. In this review, we focus on the biological characteristics and functions of exosomes and summarize their advantages and the latest progress in the diagnosis and treatment of urological diseases.
Identifiants
pubmed: 35777716
pii: S0304-3835(22)00293-2
doi: 10.1016/j.canlet.2022.215809
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
215809Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.