Association Between Sites of Metastasis and Outcomes With Immune Checkpoint Inhibitors in Advanced Urothelial Carcinoma.


Journal

Clinical genitourinary cancer
ISSN: 1938-0682
Titre abrégé: Clin Genitourin Cancer
Pays: United States
ID NLM: 101260955

Informations de publication

Date de publication:
10 2022
Historique:
received: 23 03 2022
revised: 01 06 2022
accepted: 01 06 2022
pubmed: 2 7 2022
medline: 28 9 2022
entrez: 1 7 2022
Statut: ppublish

Résumé

Sites of metastasis have prognostic significance in advanced urothelial carcinoma (aUC), but more information is needed regarding outcomes based on metastatic sites in patients treated with immune checkpoint inhibitors (ICI). We hypothesized that presence of liver/bone metastases would be associated with worse outcomes with ICI. We identified a retrospective cohort of patients with aUC across 26 institutions, collecting demographics, clinicopathological, treatment, and outcomes information. Outcomes were compared with logistic (observed response rate; ORR) and Cox (progression-free survival; PFS, overall survival; OS) regression between patients with/without metastasis beyond lymph nodes (LN) and those with/without bone/liver/lung metastasis. Analysis was stratified by 1st or 2nd We identified 917 ICI-treated patients: in the 1st line, bone/liver metastases were associated with shorter PFS (Hazard ratio; HR: 1.65 and 2.54), OS (HR: 1.60 and 2.35, respectively) and lower ORR (OR: 0.48 and 0.31). In the 2nd Bone and/or liver metastases were associated with worse, while LN-confined metastases were associated with better outcomes in patients with aUC receiving ICI. These findings in a large population treated outside clinical trials corroborate data from trial subset analyses.

Sections du résumé

BACKGROUND
Sites of metastasis have prognostic significance in advanced urothelial carcinoma (aUC), but more information is needed regarding outcomes based on metastatic sites in patients treated with immune checkpoint inhibitors (ICI). We hypothesized that presence of liver/bone metastases would be associated with worse outcomes with ICI.
METHODS
We identified a retrospective cohort of patients with aUC across 26 institutions, collecting demographics, clinicopathological, treatment, and outcomes information. Outcomes were compared with logistic (observed response rate; ORR) and Cox (progression-free survival; PFS, overall survival; OS) regression between patients with/without metastasis beyond lymph nodes (LN) and those with/without bone/liver/lung metastasis. Analysis was stratified by 1st or 2nd
RESULTS
We identified 917 ICI-treated patients: in the 1st line, bone/liver metastases were associated with shorter PFS (Hazard ratio; HR: 1.65 and 2.54), OS (HR: 1.60 and 2.35, respectively) and lower ORR (OR: 0.48 and 0.31). In the 2nd
CONCLUSION
Bone and/or liver metastases were associated with worse, while LN-confined metastases were associated with better outcomes in patients with aUC receiving ICI. These findings in a large population treated outside clinical trials corroborate data from trial subset analyses.

Identifiants

pubmed: 35778337
pii: S1558-7673(22)00125-2
doi: 10.1016/j.clgc.2022.06.001
pmc: PMC10257151
mid: NIHMS1900260
pii:
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e440-e452

Subventions

Organisme : Department of Health
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : Wellcome Trust
ID : PS3416
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : T32 CA094880
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

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Auteurs

Dimitrios Makrakis (D)

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA.

Rafee Talukder (R)

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA.

Genevieve Ihsiu Lin (GI)

Department of Epidemiology, University of Washington, Seattle, WA.

Leonidas N Diamantopoulos (LN)

Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Scott Dawsey (S)

Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.

Shilpa Gupta (S)

Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.

Lucia Carril-Ajuria (L)

Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Daniel Castellano (D)

Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Ivan de Kouchkovsky (I)

Division of Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.

Vadim S Koshkin (VS)

Division of Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.

Joseph J Park (JJ)

Division of Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI.

Ajjai Alva (A)

Division of Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI.

Mehmet A Bilen (MA)

Winship Cancer Institute of Emory University, Atlanta, GA.

Tyler F Stewart (TF)

Division of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, CA.

Rana R McKay (RR)

Division of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, CA.

Nishita Tripathi (N)

Division of Oncology, Department of Medicine, University of Utah, Salt Lake City, UT.

Neeraj Agarwal (N)

Division of Oncology, Department of Medicine, University of Utah, Salt Lake City, UT.

Naomi Vather-Wu (N)

Department of Medicine, University of Iowa, Iowa City, IA.

Yousef Zakharia (Y)

Division of Oncology, Department of Medicine, University of Iowa, Iowa City, IA.

Rafael Morales-Barrera (R)

Vall d'Hebron Institute of Oncology, Vall d' Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

Michael E Devitt (ME)

Division of Hematology/Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.

Alessio Cortellini (A)

Department of Surgery and Cancer, Imperial College London, London, UK.

Claudia Angela Maria Fulgenzi (CAM)

Department of Surgery and Cancer, Imperial College London, London, UK.

David J Pinato (DJ)

Department of Surgery and Cancer, Imperial College London, London, UK.

Ariel Nelson (A)

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.

Christopher J Hoimes (CJ)

Division of Medical Oncology, Seidman Cancer Center at Case Comprehensive Cancer Center, Cleveland, OH; Division of Medical Oncology, Duke University, Durham, NC.

Kavita Gupta (K)

Departments of Medical Oncology and Urology, Montefiore Medical Center, Bronx, NY.

Benjamin A Gartrell (BA)

Departments of Medical Oncology and Urology, Montefiore Medical Center, Bronx, NY.

Alex Sankin (A)

Departments of Medical Oncology and Urology, Montefiore Medical Center, Bronx, NY.

Abhishek Tripathi (A)

Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Roubini Zakopoulou (R)

Department of Clinical Therapeutics, Alexandra General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Aristotelis Bamias (A)

2nd Propaedeutic Dept of Internal Medicine, ATTIKON University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Jure Murgic (J)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb.

Ana Fröbe (A)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb; School of Dental Medicine, Zagreb, Croatia.

Alejo Rodriguez-Vida (A)

Medical Oncology Department, Hospital del Mar Research Institute, Barcelona, Spain.

Alexandra Drakaki (A)

Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Sandy Liu (S)

Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Eric Lu (E)

Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Vivek Kumar (V)

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Giuseppe Di Lorenzo (GD)

Oncology University of Molise and Medical Oncology ASL, Salerno, Italy.

Monika Joshi (M)

Division of Hematology/Oncology, Department of Medicine, Penn State Cancer Institute, Hershey, PA.

Pedro Isaacsson-Velho (P)

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Division of Oncology, Hospital Moinhos de Vento, Porto Alegre, Brazil.

Lucia Alonso Buznego (LA)

Hospital Universitario Marques de Valdecilla. IDIVAL. Santander, Spain.

Ignacio Duran (I)

Hospital Universitario Marques de Valdecilla. IDIVAL. Santander, Spain.

Marcus Moses (M)

Deming Department of Medicine, Section of Hematology/Oncology, Tulane University, New Orleans, LA.

Albert Jang (A)

Deming Department of Medicine, Section of Hematology/Oncology, Tulane University, New Orleans, LA.

Pedro Barata (P)

Deming Department of Medicine, Section of Hematology/Oncology, Tulane University, New Orleans, LA.

Guru Sonpavde (G)

Genitourinary Oncology Program, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Evan Y Yu (EY)

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA.

Robert Bruce Montgomery (RB)

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA.

Petros Grivas (P)

Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA. Electronic address: pgrivas@uw.edu.

Ali Raza Khaki (AR)

Division of Oncology, Department of Medicine, Stanford University, Palo Alto, CA. Electronic address: alikhaki@stanford.edu.

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Classifications MeSH