Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
01 07 2022
Historique:
received: 17 07 2021
accepted: 21 06 2022
entrez: 1 7 2022
pubmed: 2 7 2022
medline: 8 7 2022
Statut: epublish

Résumé

Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, and is required for lung tumor growth in multiple mouse models. CD4

Identifiants

pubmed: 35778404
doi: 10.1038/s41467-022-31596-7
pii: 10.1038/s41467-022-31596-7
pmc: PMC9249769
doi:

Substances chimiques

IL9 protein, human 0
Interleukin-9 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3811

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI085046
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129241
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA232491
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121176
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI060519
Pays : United States
Organisme : BLRD VA
ID : I01 BX005353
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Yongyao Fu (Y)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Abigail Pajulas (A)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Jocelyn Wang (J)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Baohua Zhou (B)

Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Anthony Cannon (A)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Cherry Cheuk Lam Cheung (CCL)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Jilu Zhang (J)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Huaxin Zhou (H)

Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Amanda Jo Fisher (AJ)

Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

David T Omstead (DT)

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.

Sabrina Khan (S)

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.

Lei Han (L)

Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Jean-Christophe Renauld (JC)

Ludwig Institute for Cancer Research, Experimental Medicine Unit, Université Catholique de Louvain, Brussels, 1200, Belgium.

Sophie Paczesny (S)

Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC, 29425, USA.

Hongyu Gao (H)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Yunlong Liu (Y)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Lei Yang (L)

Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Robert M Tighe (RM)

Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, 27710, USA.

Paula Licona-Limón (P)

Departamento de Biologia Celular y del Desarrollo, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico.

Richard A Flavell (RA)

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06510, USA.

Shogo Takatsuka (S)

Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.

Daisuke Kitamura (D)

Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.

Jie Sun (J)

Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Basar Bilgicer (B)

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.

Catherine R Sears (CR)

Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Kai Yang (K)

Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Mark H Kaplan (MH)

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkaplan2@iupui.edu.

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