The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro.
Apoptosis
Essential oil
Nigella sativa
Proliferation
T cells
Thymoquinone
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
24
05
2022
revised:
24
06
2022
accepted:
24
06
2022
pubmed:
3
7
2022
medline:
9
9
2022
entrez:
2
7
2022
Statut:
ppublish
Résumé
In previous work, we tested the immunomodulatory effect of Nigella sativa (NS) fatty oil. Our results demonstrated that unrefined, obtained by cold pressing black cumin seed oil inhibited lymphocytes' proliferation and induced their apoptosis in a dose-dependent manner. In this study, we examined the immunomodulatory properties of essential oil (EO) obtained from the NS seeds by hydrodistillation and its two main constituents: thymoquinone (TQ) and p-cymene. We analyzed the proliferation, activation phenotype, and apoptosis rates of human T lymphocytes stimulated with an immobilized monoclonal anti-CD3 antibody in the presence of serial ethanol dilutions of tested oil or serial distilled water dilutions of tested compounds with flow cytometry. Our results showed that NSEO significantly inhibited the proliferation of CD4
Identifiants
pubmed: 35779419
pii: S0753-3322(22)00738-7
doi: 10.1016/j.biopha.2022.113349
pii:
doi:
Substances chimiques
Benzoquinones
0
Oils, Volatile
0
Plant Oils
0
caraway oil
C2J9B08Q3I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113349Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement The authors declare no conflict of interest.