mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model.

8-Hydroxy-2'-Deoxyguanosine Aging / physiology Animals Beclin-1 / genetics Caspase 3 / metabolism DNA, Mitochondrial / genetics Disease Models, Animal Ki-67 Antigen / metabolism Matrix Metalloproteinase 13 / metabolism Mice Mice, Inbred C57BL Mitochondria / metabolism Osteoarthritis / genetics beta-Galactosidase / metabolism
autophagy conplastic mice mtDNA oxidative stress senescence

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
02 Jul 2022
Historique:
received: 20 10 2021
accepted: 14 06 2022
pubmed: 3 7 2022
medline: 25 8 2022
entrez: 2 7 2022
Statut: ppublish

Résumé

Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A conplastic (BL/6

Identifiants

DOI: 10.18632/aging.204153 PMID: 35779570 PMC: PMC9417242
pubmed: 35779570
pii: 204153
doi: 10.18632/aging.204153
pmc: PMC9417242
doi:

Substances chimiques

Beclin-1 0
DNA, Mitochondrial 0
Ki-67 Antigen 0
8-Hydroxy-2'-Deoxyguanosine 88847-89-6
beta-Galactosidase EC 3.2.1.23
Caspase 3 EC 3.4.22.-
Matrix Metalloproteinase 13 EC 3.4.24.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5966-5983

Références

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Auteurs

Morena Scotece (M)

Unidad de Genómica, Grupo de Investigación de Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña 15006, Spain.

Carlos Vaamonde-García (C)

Unidad de Genómica, Grupo de Investigación de Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña 15006, Spain.
Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Biología, Campus de Zapateria, A Coruña 15011, Spain.

Ana Victoria Lechuga-Vieco (AV)

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.
CIBERES: C/ Melchor Fernández-Almagro 3, Madrid 28029, Spain.
Kennedy Institute of Rheumatology, University of Oxford, Headington, Oxford OX3 7FY, UK.

Alberto Centeno Cortés (AC)

Centro Tecnológico de Formación Xerencia de Xestión Integrada A Coruña (XXIAC), A Coruña 15006, Spain.

María Concepción Jiménez Gómez (MCJ)

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.

Purificación Filgueira-Fernández (P)

Unidad de Genómica, Grupo de Investigación de Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña 15006, Spain.
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid 28029, Spain.

Ignacio Rego-Pérez (I)

Unidad de Genómica, Grupo de Investigación de Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña 15006, Spain.

José Antonio Enríquez (JA)

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, C/ Melchor Fernández-Almagro 3, Madrid 28029, Spain.

Francisco J Blanco (FJ)

Unidad de Genómica, Grupo de Investigación de Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña 15006, Spain.
Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, A Coruña 15008, Spain.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléoside purique › Désoxyguanosine › 8-Hydroxy-2'-désoxyguanosine › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Eucaryotes › Animaux › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Bécline-1 › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases effectrices › Caspase-3 › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène KI-67 › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix Metalloproteinase 13 › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › mtDNA variability determines spontaneous joint...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Galactosidases › beta-Galactosidase › mtDNA variability determines spontaneous joint...