Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease.
Gamma heavy chain disease
Immunoassay interference
Lymphoma
Serum electrophoresis
Serum immunofixation
Journal
Clinical biochemistry
ISSN: 1873-2933
Titre abrégé: Clin Biochem
Pays: United States
ID NLM: 0133660
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
30
03
2022
revised:
20
06
2022
accepted:
25
06
2022
pubmed:
3
7
2022
medline:
21
9
2022
entrez:
2
7
2022
Statut:
ppublish
Résumé
Immunoassays are widely used in clinical laboratories because of their ease of use and low cost. These tests are based on antigen-antibody binding. However, clinicians and laboratory personnel may be confronted with immunoassay interference leading to difficulties in medical care. Here, we report a huge analytical discrepancy with IgG concentration higher than proteinemia in a 75-year-old man. Serum electrophoresis and immunofixation diagnosed γ-heavy chain disease. After investigation by different methods, the assay discrepancy was still present. We hypothesize that the interference is related to the truncated immunoglobulin secreted by the lymphoproliferative disorder.
Identifiants
pubmed: 35779576
pii: S0009-9120(22)00167-9
doi: 10.1016/j.clinbiochem.2022.06.011
pii:
doi:
Substances chimiques
Immunoglobulin G
0
Immunoglobulin Light Chains
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-13Informations de copyright
Copyright © 2022 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.