The effect of ketamine on delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb.
Delta rhythm
NMDA receptor blockade
Oscillatory synchrony
Respiratory related oscillations
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
received:
21
04
2022
revised:
23
06
2022
accepted:
26
06
2022
pubmed:
3
7
2022
medline:
10
8
2022
entrez:
2
7
2022
Statut:
ppublish
Résumé
Respiratory rhythm plays an important role in cognitive functions in rodents, as well as in humans. Respiratory related oscillation (RRO), generated in the olfactory bulb (OB), is an extrinsic rhythm imposed on brain networks. In rats, RRO can couple with intrinsic brain oscillations at theta frequency during sniffing and in the delta range outside of such episodes. Disruption of gamma synchronization in cortical networks by ketamine is well established whereas its effects on slow rhythms are poorly understood. We found in this study, that RRO in prefrontal cortex (PFC) and hippocampus (HC) remains present after ketamine injection, even on the background of highly unstable respiratory rate, co-incident with "psychotic-like" behavior and abnormal cortical gamma activity. Guided by the timing of ketamine-induced gamma reaction, pairwise coherences between structures exhibiting RRO and their correlation structure was statistically tested in 5-min segments post-injection (0-25 min) and during recovery (1, 5, 10 h). As in control, RRO in the OB was firmly followed by cortical-bound OB exits directed toward PFC but not to HC. RRO between these structures, however, significantly correlated with OB-HC but not with OB-PFC. The only exception to this general observation was observed during a short transitional period, immediately after injection. Ketamine has a remarkable history in psychiatric research. Modeling chronic NMDA-hypofunction using acute NMDA-receptor blockade shifted the primary focus of schizophrenia research to dysfunctional cortical microcircuitry and the recent discovery of ketamine's antidepressant actions extended investigations to neurophysiology of anxiety and depression. Cortical oscillations are relevant for understanding their pathomechanism.
Identifiants
pubmed: 35779582
pii: S0006-8993(22)00220-7
doi: 10.1016/j.brainres.2022.147996
pmc: PMC10038235
mid: NIHMS1877373
pii:
doi:
Substances chimiques
N-Methylaspartate
6384-92-5
Ketamine
690G0D6V8H
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
147996Subventions
Organisme : NIMH NIH HHS
ID : R01 MH100820
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH127483
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Références
Brain Struct Funct. 2018 Jan;223(1):1-3
pubmed: 29222724
Sleep. 2012 Jul 01;35(7):1011-6
pubmed: 22754048
J Neurosci. 1995 Jan;15(1 Pt 1):47-60
pubmed: 7823151
Neuropsychopharmacology. 2010 Feb;35(3):632-40
pubmed: 19890262
J Neurosci. 2014 Apr 23;34(17):5949-64
pubmed: 24760854
Percept Mot Skills. 2013 Feb;116(1):1-20
pubmed: 23829130
PLoS One. 2018 Sep 14;13(9):e0204021
pubmed: 30216372
Brain Struct Funct. 2012 Apr;217(2):395-409
pubmed: 21979451
Behav Biol. 1975 Jul;14(3):295-308
pubmed: 1137549
Front Neural Circuits. 2018 Aug 13;12:61
pubmed: 30150926
Sci Rep. 2021 Apr 14;11(1):8100
pubmed: 33854115
Sci Rep. 2018 Aug 2;8(1):11588
pubmed: 30072757
Respir Physiol Neurobiol. 2022 Jan;295:103781
pubmed: 34481078
Brain Struct Funct. 2018 Jan;223(1):5-9
pubmed: 29222725
Neuroimage Clin. 2014 Jul 24;5:298-308
pubmed: 25161896
Neuropsychopharmacology. 2007 Mar;32(3):719-27
pubmed: 16525415
Brain Res Cogn Brain Res. 2004 Mar;19(1):1-9
pubmed: 14972353
Annu Rev Med. 2015;66:509-23
pubmed: 25341010
Eur J Neurosci. 2014 Mar;39(6):957-974
pubmed: 24329896
Eur J Neurosci. 2018 Oct;48(8):2903-2914
pubmed: 29359413
Eur J Neurosci. 2021 Aug;54(4):5507-5517
pubmed: 34237172
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8496-501
pubmed: 17483481
Annu Rev Neurosci. 2018 Jul 8;41:475-499
pubmed: 29709210
Neuron. 2019 Mar 6;101(5):774-778
pubmed: 30844397
Trends Neurosci. 2009 Jan;32(1):9-18
pubmed: 19012975
Neuron. 2011 Oct 6;72(1):153-65
pubmed: 21982376
Neuron. 2014 Sep 3;83(5):1185-99
pubmed: 25132467
J Neurophysiol. 2005 Sep;94(3):1904-11
pubmed: 15901760
Nat Commun. 2018 Apr 18;9(1):1528
pubmed: 29670106
Psychophysiology. 1991 Mar;28(2):217-24
pubmed: 1946887
Neuroscience. 2011 Dec 29;199:51-63
pubmed: 22027237
Nature. 2016 Jul 21;535(7612):420-4
pubmed: 27409809
Sci Rep. 2018 Apr 24;8(1):6432
pubmed: 29691421
Ann N Y Acad Sci. 2003 Nov;1003:318-27
pubmed: 14684455
J Neurosci. 2016 Jan 06;36(1):162-77
pubmed: 26740658
J Neurosci. 2010 Sep 15;30(37):12424-31
pubmed: 20844137
Sleep Med. 2014 Oct;15(10):1184-95
pubmed: 25192672
J Neurosci. 2012 Jan 11;32(2):423-35
pubmed: 22238079
Front Syst Neurosci. 2018 Jun 05;12:25
pubmed: 29937718
Neuroimage. 2015 Oct 15;120:481-92
pubmed: 26169319
Trends Neurosci. 2017 Jun;40(6):371-382
pubmed: 28515010
Biol Psychiatry. 2021 Jul 15;90(2):85-95
pubmed: 33568318
Eur J Appl Physiol. 2003 Sep;90(1-2):125-30
pubmed: 12827368
Auton Neurosci. 2004 Sep 30;115(1-2):82-93
pubmed: 15507409
J Neurophysiol. 2013 Jan;109(2):570-9
pubmed: 23114214
Physiol Rev. 2012 Jul;92(3):1087-187
pubmed: 22811426
Prog Brain Res. 2007;165:201-20
pubmed: 17925248
Brain Struct Funct. 2018 Jan;223(1):11-16
pubmed: 29222723
J Neurosci. 2009 Jun 24;29(25):8215-24
pubmed: 19553461
J Appl Physiol (1985). 1992 Apr;72(4):1595-603
pubmed: 1592753
Biol Psychiatry. 2008 Apr 15;63(8):730-5
pubmed: 18022604
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15085-90
pubmed: 23980180
Curr Biol. 2017 Mar 6;27(5):688-696
pubmed: 28216320
Trends Neurosci. 2018 Apr;41(4):186-197
pubmed: 29429805
J Neurosci. 2016 Dec 7;36(49):12448-12467
pubmed: 27927961
Nature. 2010 Apr 1;464(7289):763-7
pubmed: 20360742
Front Neurosci. 2008 Dec 15;2(2):145-54
pubmed: 19225587
Sci Rep. 2021 Mar 29;11(1):7044
pubmed: 33782487
Motor Control. 2012 Oct;16(4):493-505
pubmed: 22643317
J Neurosci. 2018 Nov 28;38(48):10286-10294
pubmed: 30348674
Med Biol Eng Comput. 2000 Jul;38(4):416-26
pubmed: 10984940
CNS Neurosci Ther. 2013 Jun;19(6):437-47
pubmed: 23611295
Nat Neurosci. 2016 Apr;19(4):605-12
pubmed: 26878674
Curr Biol. 2015 Dec 21;25(24):3196-201
pubmed: 26628008
Science. 2006 Sep 15;313(5793):1626-8
pubmed: 16973878
Brain Struct Funct. 2017 Aug;222(6):2819-2830
pubmed: 28210848
Trends Cogn Sci. 2010 Nov;14(11):506-15
pubmed: 20932795
Nat Hum Behav. 2019 May;3(5):501-512
pubmed: 31089297
Nat Rev Neurosci. 2006 Mar;7(3):232-42
pubmed: 16495944
Schizophr Bull. 2008 Sep;34(5):974-80
pubmed: 18559405
Neuron. 2011 Sep 22;71(6):962-73
pubmed: 21943596
Pain. 2017 Jun;158(6):995-1006
pubmed: 28240995
Brain Topogr. 2009 Jun;22(1):24-6
pubmed: 19205863
J Neurophysiol. 2019 Aug 1;122(2):563-571
pubmed: 31215344
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3863-8
pubmed: 15738424