Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience.
COVID-19
Critical care
Pandemic
Perspectives
Research
Journal
Anaesthesia, critical care & pain medicine
ISSN: 2352-5568
Titre abrégé: Anaesth Crit Care Pain Med
Pays: France
ID NLM: 101652401
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
18
03
2022
revised:
03
06
2022
accepted:
03
06
2022
pubmed:
6
7
2022
medline:
15
9
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
While the coronavirus disease 2019 (COVID-19) pandemic placed a heavy burden on healthcare systems worldwide, it also induced urgent mobilisation of research teams to develop treatments preventing or curing the disease and its consequences. It has, therefore, challenged critical care research to rapidly focus on specific fields while forcing critical care physicians to make difficult ethical decisions. This narrative review aims to summarise critical care research -from organisation to research fields- in this pandemic setting and to highlight opportunities to improve research efficiency in the future, based on what is learned from COVID-19. This pressure on research revealed, i.e., (i) the need to harmonise regulatory processes between countries, allowing simplified organisation of international research networks to improve their efficiency in answering large-scale questions; (ii) the importance of developing translational research from which therapeutic innovations can emerge; (iii) the need for improved triage and predictive scores to rationalise admission to the intensive care unit. In this context, key areas for future critical care research and better pandemic preparedness are artificial intelligence applied to healthcare, characterisation of long-term symptoms, and ethical considerations. Such collaborative research efforts should involve groups from both high and low-to-middle income countries to propose worldwide solutions. As a conclusion, stress tests on healthcare organisations should be viewed as opportunities to design new research frameworks and strategies. Worldwide availability of research networks ready to operate is essential to be prepared for next pandemics. Importantly, researchers and physicians should prioritise realistic and ethical goals for both clinical care and research.
Identifiants
pubmed: 35781076
pii: S2352-5568(22)00102-3
doi: 10.1016/j.accpm.2022.101121
pmc: PMC9245393
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101121Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Références
Crit Care. 2020 Mar 24;24(1):101
pubmed: 32204716
BMC Health Serv Res. 2021 Aug 21;21(1):847
pubmed: 34419032
J Clin Invest. 2020 Jun 1;130(6):2745-2748
pubmed: 32243259
N Engl J Med. 2020 May 14;382(20):1873-1875
pubmed: 32187459
Nature. 2020 May;581(7807):130-131
pubmed: 32382120
Lancet Respir Med. 2021 Sep;9(9):939-941
pubmed: 34224679
N Engl J Med. 2021 Feb 11;384(6):497-511
pubmed: 33264556
Crit Care. 2020 May 26;24(1):265
pubmed: 32456690
Crit Care. 2020 Jun 5;24(1):293
pubmed: 32503593
N Engl J Med. 2012 Mar 1;366(9):782-3
pubmed: 22375968
Ann Intern Med. 2020 Oct 20;173(8):652-653
pubmed: 32543881
Cell Rep Med. 2022 Jul 19;3(7):100680
pubmed: 35839768
Can J Surg. 2020 May 1;63(22):S2-S4
pubmed: 32343118
Sci Prog. 2021 Apr-Jun;104(2):368504211016936
pubmed: 33989091
Emerg Med J. 2020 Sep;37(9):572-575
pubmed: 32651176
Anaesth Crit Care Pain Med. 2019 Aug;38(4):377-384
pubmed: 30339893
JAMA. 2018 Apr 3;319(13):1317-1318
pubmed: 29532063
Crit Care. 2015 Jun 12;19:254
pubmed: 26070457
Nat Rev Immunol. 2021 Jun;21(6):382-393
pubmed: 33875867
Public Health. 2003 Jul;117(4):274-80
pubmed: 12966750
N Engl J Med. 2020 May 21;382(21):2049-2055
pubmed: 32202722
PLoS One. 2015 Dec 22;10(12):e0144801
pubmed: 26693728
JAMA. 2008 Dec 3;300(21):2506-13
pubmed: 19050194
Lancet Respir Med. 2020 Aug;8(8):807-815
pubmed: 32422178
Cell Rep Med. 2021 May 18;2(5):100287
pubmed: 33969320
N Engl J Med. 2013 Nov 21;369(21):2054-9
pubmed: 24256385
Crit Care Med. 2019 Jan;47(1):3-14
pubmed: 30339549
N Engl J Med. 2021 Jul 1;385(1):7-9
pubmed: 33761205
J Med Internet Res. 2020 Jun 10;22(6):e15471
pubmed: 32519972
Anaesth Intensive Care. 2018 May;46(3):304-312
pubmed: 29716489
Infect Control Hosp Epidemiol. 2021 Jun 24;:1-4
pubmed: 34167599
Int J Public Health. 2020 Jun;65(5):533-546
pubmed: 32451563
Crit Care Med. 2018 Sep;46(9):e825-e873
pubmed: 30113379
Intensive Care Med. 2021 Mar;47(3):282-291
pubmed: 33616696
Crit Care Med. 2018 Sep;46(9):1393-1401
pubmed: 29787415
Lancet. 2001 Aug 4;358(9279):397-400
pubmed: 11502338
JAMA. 2020 Oct 6;324(13):1307-1316
pubmed: 32876695
Science. 2020 May 22;368(6493):810-811
pubmed: 32439771
Sci Data. 2016 Mar 15;3:160018
pubmed: 26978244
Resuscitation. 2010 Apr;81(4):375-82
pubmed: 20149516
Nature. 2021 Jun;594(7862):259-264
pubmed: 33887749
JAMA Netw Open. 2021 Mar 1;4(3):e210417
pubmed: 33666657
Lancet Respir Med. 2021 Mar;9(3):239-250
pubmed: 33428871
Sci Immunol. 2020 Dec 7;5(54):
pubmed: 33288645
Nature. 2021 Mar;591(7849):234-239
pubmed: 33692557
Crit Care Med. 2019 Oct;47(10):1283-1289
pubmed: 31343475
Crit Care. 2020 Oct 15;24(1):608
pubmed: 33059761
Cell Rep Med. 2020 Dec 26;2(1):100166
pubmed: 33521697
Am J Trop Med Hyg. 2021 Jan 06;104(3_Suppl):1-2
pubmed: 33410393
J Am Med Inform Assoc. 2012 Jun;19(e1):e145-8
pubmed: 22534081
BMJ Open. 2017 Jan 27;7(1):e012332
pubmed: 28131997
Am J Emerg Med. 2021 Jan;39:221-222
pubmed: 32402498
JNMA J Nepal Med Assoc. 2021 Apr 30;59(236):429-431
pubmed: 34508518
Biomedicines. 2021 Aug 05;9(8):
pubmed: 34440170
N Engl J Med. 2020 Dec 10;383(24):2389-2390
pubmed: 33216474
J Clin Med. 2020 Jun 19;9(6):
pubmed: 32575380
Intensive Care Med. 2021 Jul;47(7):750-760
pubmed: 34089064
Eur J Prev Cardiol. 2020 Sep;27(13):1442-1446
pubmed: 32551971
N Engl J Med. 2021 Aug 26;385(9):777-789
pubmed: 34351722
Science. 2021 Oct 22;374(6566):472-478
pubmed: 34554826
J Crit Care. 2021 Feb;61:241-246
pubmed: 33220577
BMJ Open. 2021 Dec 6;11(12):e049086
pubmed: 34872995
Am J Respir Crit Care Med. 2006 Feb 1;173(3):256-63
pubmed: 16239619
Crit Care. 2021 Jan 28;25(1):40
pubmed: 33509218
Nat Commun. 2021 Oct 26;12(1):6188
pubmed: 34702862
Crit Care Med. 2021 Aug 1;49(8):1227-1240
pubmed: 34115639
Cell. 2020 Dec 10;183(6):1479-1495.e20
pubmed: 33171100
Crit Care Explor. 2021 Mar 12;3(3):e0353
pubmed: 33786432
Crit Care Med. 2020 Apr;48(4):e285-e289
pubmed: 32205618
BMJ. 2020 Jul 30;370:m2980
pubmed: 32732190
Crit Care Med. 2021 Sep 1;49(9):1427-1438
pubmed: 33769771
Lancet Respir Med. 2021 Aug;9(8):933-936
pubmed: 33915103
Anaesthesia. 2021 Apr;76(4):537-548
pubmed: 33525063
Am J Respir Crit Care Med. 2021 Jan 1;203(1):125-127
pubmed: 33125253
JAMA Intern Med. 2021 Aug 1;181(8):1065-1070
pubmed: 34152373
JAMA Netw Open. 2021 Jun 1;4(6):e2113355
pubmed: 34152418
Crit Care Explor. 2021 Aug 19;3(8):e0516
pubmed: 34476403
Lancet Respir Med. 2020 May;8(5):506-517
pubmed: 32272080
Eur Respir Rev. 2021 Feb 2;30(159):
pubmed: 33536264
Int J Surg. 2020 Jul;79:180-188
pubmed: 32454253
J Matern Fetal Neonatal Med. 2021 Mar 02;:1-8
pubmed: 33653202
BMJ Support Palliat Care. 2020 Oct 15;:
pubmed: 33060189
Cell. 2020 Sep 17;182(6):1419-1440.e23
pubmed: 32810438
Cell. 2020 Sep 17;182(6):1401-1418.e18
pubmed: 32810439
PLoS Med. 2021 Jul 27;18(7):e1003699
pubmed: 34314418
Trials. 2021 May 5;22(1):328
pubmed: 33952318
J Healthc Qual. 2021 Jan-Feb 01;43(1):59-66
pubmed: 32604130
Lancet. 2021 Jun 12;397(10291):2253-2263
pubmed: 34097856
Crit Care Med. 2021 Jun 1;49(6):e598-e612
pubmed: 33729718
BMJ Health Care Inform. 2021 Sep;28(1):
pubmed: 34521623
Neurodegener Dis Manag. 2021 Feb;11(1):83-89
pubmed: 33172352
Lancet Glob Health. 2021 May;9(5):e711-e720
pubmed: 33865476
Lancet. 2021 Aug 28;398(10302):747-758
pubmed: 34454673
Lancet. 2020 Jun 13;395(10240):1820
pubmed: 32511943
JAMA. 2016 Feb 23;315(8):753-4
pubmed: 26903331
JAMA. 2014 Jun 25;311(24):2479-80
pubmed: 24854141
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
J Nurs Care Qual. 2019 Apr/Jun;34(2):107-113
pubmed: 30095509
Lancet Respir Med. 2021 Nov;9(11):1275-1287
pubmed: 34627560
Intensive Care Med. 2016 Jun;42(6):962-71
pubmed: 27075762
JAMA. 2020 May 12;323(18):1773-1774
pubmed: 32219367
JAMA. 2020 Aug 4;324(5):453-454
pubmed: 32589195