Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens.

Humans Precision Medicine Neurodegenerative Diseases Optical Imaging / methods Molecular Imaging Brain Neoplasms Fluorescent Dyes / chemistry
Aggregation-induced emission Brain vasculature Fluorescence imaging Neurological diseases Theranostics

Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
11 2022
Historique:
received: 02 05 2022
accepted: 25 06 2022
pubmed: 6 7 2022
medline: 29 10 2022
entrez: 5 7 2022
Statut: ppublish

Résumé

Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission luminogens (AIEgens) have been regarded as good candidates in many biomedical applications. They display a large Stokes shift, high quantum yield, good biocompatibility, and resistance to photobleaching. Neurological diseases are becoming a substantial burden on individuals and society that affect over 50 million people worldwide. It is urgently needed to explore in more detail the brain structure and function, learn more about pathological processes of neurological diseases, and develop more efficient approaches for theranostics. Many AIEgens have been successfully designed, synthesized, and further applied for molecular imaging and image-guided theranostics in neurological diseases such as cerebrovascular disease, neurodegenerative disease, and brain tumor, which help us understand more about the pathophysiological state of brain through noninvasive optical imaging approaches. Herein, we focus on representative AIEgens investigated on brain vasculature imaging and theranostics in neurological diseases including cerebrovascular disease, neurodegenerative disease, and brain tumor. Considering different imaging modalities and various therapeutic functions, AIEgens have great potential to broaden neurological research and meet urgent needs in clinical practice. It will be inspiring to develop more practical and versatile AIEgens as molecular imaging agents for preclinical and clinical use on neurological diseases.

Identifiants

DOI: 10.1007/s00259-022-05894-7 PMID: 35781601 PMC: PMC9606072
pubmed: 35781601
doi: 10.1007/s00259-022-05894-7
pii: 10.1007/s00259-022-05894-7
pmc: PMC9606072
doi:

Substances chimiques

Fluorescent Dyes 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4529-4550

Informations de copyright

© 2022. The Author(s).

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Auteurs

Peili Cen (P)

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31009, Zhejiang, China.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 31009, Zhejiang, China.
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 31009, Zhejiang, China.

Youyou Zhou (Y)

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31009, Zhejiang, China.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 31009, Zhejiang, China.
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 31009, Zhejiang, China.

Chunyi Cui (C)

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31009, Zhejiang, China.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 31009, Zhejiang, China.
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 31009, Zhejiang, China.

Yen Wei (Y)

Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, China.

Zhen Cheng (Z)

Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Shuizhu Wu (S)

State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence From Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Wushan Road 381, Guangzhou, 510640, China.

Hong Zhang (H)

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31009, Zhejiang, China. hzhang21@zju.edu.cn.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 31009, Zhejiang, China. hzhang21@zju.edu.cn.
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 31009, Zhejiang, China. hzhang21@zju.edu.cn.
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, 310014, Zhejiang, China. hzhang21@zju.edu.cn.
Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310014, Zhejiang, China. hzhang21@zju.edu.cn.
ORCID: 0000-0002-4084-5150

Mei Tian (M)

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31009, Zhejiang, China. meitian@zju.edu.cn.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 31009, Zhejiang, China. meitian@zju.edu.cn.
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 31009, Zhejiang, China. meitian@zju.edu.cn.

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questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Optical molecular imaging and theranostics in...
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questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Optical molecular imaging and theranostics in...
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questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Optical molecular imaging and theranostics in...