Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient.
antisense
chronic pain
implantable drug delivery system (IDDS)
intrathecal
neuromodulation
Journal
Frontiers in pain research (Lausanne, Switzerland)
ISSN: 2673-561X
Titre abrégé: Front Pain Res (Lausanne)
Pays: Switzerland
ID NLM: 9918227269806676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
03
2022
accepted:
02
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output, defining the motor response of the organism, along with the unique biology and spatial organization of this space, have resulted in an increased focus on therapeutics targeted at this extracranial neuraxial space. Intrathecal (IT) drug delivery systems (IDDS) are well-established as an effective therapeutic approach to patients with chronic non-malignant or malignant pain and as a tool for management of patients with severe spasticity and to deliver therapeutics that address a myriad of spinal pathologies. The risk to benefit ratio of IDD makes it a useful interventional approach. While not without risks, this approach has a significant therapeutic safety margin when employed using drugs with a validated safety profile and by skilled practioners. The present review addresses current advances in our understanding of the biology and dynamics of the intrathecal space, therapeutic platforms, novel therapeutics, delivery technology, issues of safety and rational implementation of its therapy, with a particular emphasis upon the management of pain.
Identifiants
pubmed: 35782225
doi: 10.3389/fpain.2022.900566
pmc: PMC9246706
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
900566Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 De Andres, Hayek, Perruchoud, Lawrence, Reina, De Andres-Serrano, Rubio-Haro, Hunt and Yaksh.
Déclaration de conflit d'intérêts
CP is a consultant for Medtronic (honoraria for scientific advisory board and consultation fees). TY holds consulting agreements with Medtronic and Sorrento and is on the SAB for Raft and Navega. TY and MH hold a patent for an intrathecal catheter described herein. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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