Increased atherosclerosis in a mouse model of glycogen storage disease type 1a.
Atherosclerosis
G6P, Glucose-6-phosphate
G6PC1, Glucose-6-phosphatase enzyme
GSD Ia, Glycogen storage disease type 1a
Glycogen storage disease type 1a
HDL, High-density lipoprotein
Hyperlipidemia
Ldlr−/−, LDL receptor deficient
PUFA, Poly-unsaturated FA
SFA, Saturated fatty acids
TG, Triglycerides
VLDL, Very-low-density lipoprotein
WTD, Western-type diet
Journal
Molecular genetics and metabolism reports
ISSN: 2214-4269
Titre abrégé: Mol Genet Metab Rep
Pays: United States
ID NLM: 101624422
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
15
04
2022
accepted:
16
04
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
Identifiants
pubmed: 35782606
doi: 10.1016/j.ymgmr.2022.100872
pii: S2214-4269(22)00032-5
pmc: PMC9248218
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100872Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
None.
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