Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a (

accelerator mass spectrometry dermal bioavailability of aluminium microtracer research

Journal

Toxicology research
ISSN: 2045-452X
Titre abrégé: Toxicol Res (Camb)
Pays: England
ID NLM: 101587950

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 01 12 2021
revised: 21 03 2022
accepted: 05 05 2022
entrez: 5 7 2022
pubmed: 6 7 2022
medline: 6 7 2022
Statut: epublish

Résumé

A follow-up study was performed in 12 healthy women to evaluate systemic exposure to aluminium following topical application of a representative antiperspirant formulation under real-life use conditions (part A) and to assess the local fate of topically applied aluminium by taking additional tape strips and skin biopsies (Part B). A simple roll-on formulation, containing the maximal possible radioactive dose, was prepared with [

Identifiants

pubmed: 35782644
doi: 10.1093/toxres/tfac029
pii: tfac029
pmc: PMC9244721
doi:

Types de publication

Journal Article

Langues

eng

Pagination

511-519

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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Auteurs

Rianne de Ligt (R)

TNO, P.O. Box 2215, 2301CE Leiden, The Netherlands.

Joost Westerhout (J)

TNO, P.O. Box 80015, 3508TA Utrecht, The Netherlands.

Dimitri Grossouw (D)

TNO, P.O. Box 2215, 2301CE Leiden, The Netherlands.

Thomas P Buters (TP)

Center for Human Drug Research, 2333CL Leiden, The Netherlands.

Robert Rissmann (R)

Center for Human Drug Research, 2333CL Leiden, The Netherlands.

Jacobus Burggraaf (J)

Center for Human Drug Research, 2333CL Leiden, The Netherlands.

Albert D Windhorst (AD)

Department of Radiology and Nuclear Medicine, Free University Medical Center, P.O. Box 7057, 1007MB, Amsterdam, The Netherlands.

Sarah Tozer (S)

Procter & Gamble Technical Centres Ltd, Reading RG2 0QE, UK.

Gerlinde Pappa (G)

Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany.

Brian Wall (B)

Colgate Palmolive Company, 909 River Road, Piscataway, NJ 08855, USA.

Dagmar Bury (D)

L'Oréal Research & Innovation, 9 rue Pierre Dreyfus, 92110 Clichy, France.

David R Mason (DR)

Safety and Environmental Assurance Centre, Unilever, Colworth Science Park, Sharnbrook MK44 1LQ, UK.

Wouter H J Vaes (WHJ)

TNO, P.O. Box 2215, 2301CE Leiden, The Netherlands.

Classifications MeSH