Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats.
arsenic
immobilization stress
rats
spermatogenesis
testicular steroidogenesis
Journal
Toxicology research
ISSN: 2045-452X
Titre abrégé: Toxicol Res (Camb)
Pays: England
ID NLM: 101587950
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
06
09
2021
revised:
28
02
2022
accepted:
05
04
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
The central objective of this study was to investigate the cumulative effects restraint stress and sodium arsenite on reproductive health in male rats. Healthy male Wistar rats were allocated into 4 groups ( Restraint stress or sodium arsenite treatment increased serum corticosterone levels, reduced testicular daily sperm count, epididymal sperm viability, motility, membrane integrity, and decreased testicular steroidogenic enzymes such as 3β- and 17β-hydroxysteroid dehydrogenases associated with reduced serum testosterone levels, deteriorated testicular architecture, and reduced activity levels of testicular superoxide dismutase and catalase accompanied by elevated lipid peroxidation levels. In rats subjected to restraint stress and sodium arsenite, a significant decrease in selected sperm qualitative and quantitative parameters, serum testosterone levels were observed as compared with rats subjected to sodium arsenite alone. A significant increase in the levels of lipid peroxidation with a concomitant decrease in the activities of antioxidant enzymes was observed in the testis of rats subjected to both restraint stress and sodium arsenite treatment as compared with sodium arsenite alone intoxicated rats. Surprisingly, serum corticosterone levels were significantly elevated in rats following both stressors as compared with arsenic alone treated rats. Analysis of atomic absorption spectroscopy revealed that the accumulation of arsenic in the testis of arsenic-treated and arsenic plus immobilization stress groups was significant as compared with controls. Based on the findings, it can be concluded that deterioration of male reproductive health could be accelerated in arsenic intoxicated rats following restraint stress.
Identifiants
pubmed: 35782652
doi: 10.1093/toxres/tfac022
pii: tfac022
pmc: PMC9244228
doi:
Types de publication
Journal Article
Langues
eng
Pagination
426-436Informations de copyright
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Références
Int J Reprod Biomed. 2016 Jul;14(7):443-52
pubmed: 27525328
Reprod Toxicol. 2018 Jun;78:130-140
pubmed: 29702248
Endocrinology. 1987 Aug;121(2):561-8
pubmed: 3109884
Biol Trace Elem Res. 2013 Feb;151(2):269-76
pubmed: 23229538
Andrologia. 2000 Jan;32(1):7-11
pubmed: 10702860
Cancer Res. 2002 Jul 15;62(14):3893-903
pubmed: 12124315
Toxicol Sci. 2006 Nov;94(1):3-21
pubmed: 16807284
Int J Androl. 2009 Oct;32(5):575-85
pubmed: 18637154
Endocrinology. 1981 Jun;108(6):2142-8
pubmed: 6262050
Environ Geochem Health. 1996 Mar;18(1):5-15
pubmed: 24194364
J Biochem Mol Toxicol. 2018 Feb;32(2):
pubmed: 29214690
Endocr Rev. 2001 Aug;22(4):502-48
pubmed: 11493581
Mol Cell Endocrinol. 2006 May 16;250(1-2):66-9
pubmed: 16412557
Syst Biol Reprod Med. 2013 Aug;59(4):199-209
pubmed: 23651453
Free Radic Biol Med. 2011 Jul 15;51(2):257-81
pubmed: 21554949
Andrology. 2019 Sep;7(5):730-740
pubmed: 31207180
Indian J Biochem Biophys. 2005 Feb;42(1):48-53
pubmed: 23923581
Nat Rev Urol. 2015 Jul;12(7):373-82
pubmed: 26057063
J Nutr Biochem. 2005 Oct;16(10):577-86
pubmed: 16111877
J Toxicol. 2011;2011:431287
pubmed: 22174709
Arch Androl. 1992 Sep-Oct;29(2):105-16
pubmed: 1456832
Sci Rep. 2016 Sep 02;6:32518
pubmed: 27585557
Physiol Res. 2020 Sep 30;69(Suppl 2):S205-S210
pubmed: 33094619
ISRN Urol. 2013 Nov 06;2013:278720
pubmed: 24307953
J Toxicol Environ Health A. 2016;79(6):274-86
pubmed: 27029432
Steroids. 2008 Oct;73(9-10):1018-24
pubmed: 18281069
Genes Environ. 2016 Feb 19;38:4
pubmed: 27350824
J Biol Chem. 1972 May 25;247(10):3170-5
pubmed: 4623845
Indian J Med Res. 2009 Apr;129(4):357-67
pubmed: 19535829
Environ Int. 2016 Oct;95:61-8
pubmed: 27502899
Anal Biochem. 1979 Jun;95(2):351-8
pubmed: 36810
Psychoneuroendocrinology. 1996 Jan;21(1):39-50
pubmed: 8778903
J Exp Zool. 1981 Feb;215(2):201-8
pubmed: 6168732
Int J Mol Sci. 2014 Nov 14;15(11):21028-44
pubmed: 25405735
Toxicol Rep. 2017 Jun 23;4:373-381
pubmed: 28959662
J Trace Elem Med Biol. 2011 Dec;25(4):247-53
pubmed: 21924885
J Reprod Fertil. 1978 Sep;54(1):103-7
pubmed: 712697
FASEB J. 2008 Mar;22(3):659-61
pubmed: 17942826
Reprod Biol Endocrinol. 2006 Feb 16;4:9
pubmed: 16483355
Dev Reprod. 2015 Dec;19(4):167-80
pubmed: 26973968
Environ Sci Pollut Res Int. 2016 Sep;23(18):18200-10
pubmed: 27265425
Toxins (Basel). 2010 Jun;2(6):1357-80
pubmed: 22069642
J Exp Zool A Ecol Genet Physiol. 2012 Aug;317(7):455-65
pubmed: 22753343
Reprod Toxicol. 1992;6(6):491-505
pubmed: 1288759
J Basic Clin Physiol Pharmacol. 2013;24(4):245-53
pubmed: 23950573
Syst Biol Reprod Med. 2015 Jun;61(3):150-60
pubmed: 25640572
J Androl. 2006 Sep-Oct;27(5):619-26
pubmed: 16751621
J Toxicol Environ Health A. 2017;80(19-21):1166-1179
pubmed: 28956719
J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):242-9
pubmed: 20806395
Toxicology. 2008 Feb 28;244(2-3):190-7
pubmed: 18248869
Biomed Res Int. 2014;2014:761264
pubmed: 24587990
Chemosphere. 2020 Jan;238:124650
pubmed: 31472347
Hum Exp Toxicol. 2004 Aug;23(8):399-403
pubmed: 15346721
Ecotoxicol Environ Saf. 2011 May;74(4):793-9
pubmed: 21112632
Methods Enzymol. 1984;105:121-6
pubmed: 6727660
Lancet. 1998 Oct 10;352(9135):1172-7
pubmed: 9777833
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
J Nanobiotechnology. 2017 Jun 2;15(1):42
pubmed: 28578696
J Lab Clin Med. 1953 Mar;41(3):486-92
pubmed: 13035283
World J Urol. 2003 Nov;21(5):341-5
pubmed: 14566423