Bursts of Genomic Instability Potentiate Phenotypic and Genomic Diversification in
aneuploidy
genome evolution
genomic instability
phenotypic plasticity
punctuated equilibrium
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
04
2022
accepted:
24
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
How microbial cells leverage their phenotypic potential to survive in a changing environment is a complex biological problem, with important implications for pathogenesis and species evolution. Stochastic phenotype switching, a particularly fascinating adaptive approach observed in numerous species across the tree of life, introduces phenotypic diversity into a population through mechanisms which have remained difficult to define. Here we describe our investigations into the mechanistic basis of colony morphology phenotype switching which occurs in populations of a pathogenic isolate of
Identifiants
pubmed: 35783258
doi: 10.3389/fgene.2022.912851
pii: 912851
pmc: PMC9247159
doi:
Types de publication
Journal Article
Langues
eng
Pagination
912851Subventions
Organisme : NIGMS NIH HHS
ID : K99 GM134193
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM134193
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119788
Pays : United States
Informations de copyright
Copyright © 2022 Heasley and Argueso.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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