Understanding the role of mechanics in nucleocytoplasmic transport.
Journal
APL bioengineering
ISSN: 2473-2877
Titre abrégé: APL Bioeng
Pays: United States
ID NLM: 101726398
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
20
10
2021
accepted:
03
02
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research.
Identifiants
pubmed: 35783457
doi: 10.1063/5.0076034
pii: 5.0076034
pmc: PMC9246425
doi:
Types de publication
Journal Article
Langues
eng
Pagination
020901Informations de copyright
© 2022 Author(s).
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