Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report.
RNAemia
convalescent plasma therapy
plasma proteomics
severe COVID-19
single-cell transcriptomics
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
04
2022
accepted:
24
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. We report a case of full resolution of severe COVID-19 due to convalescent plasma transfusion. Following transfusion, the patient showed fever remission, improved respiratory status, and rapidly decreased viral burden in respiratory fluids and SARS-CoV-2 RNAemia. Longitudinal unbiased proteomic analysis of plasma and single-cell transcriptomics of peripheral blood cells conducted prior to and at multiple times after convalescent plasma transfusion identified the key biological processes associated with the transition from severe disease to disease-free state. These included (i) temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis and (ii) post-transfusion disappearance of a subset of monocytes characterized by hyperactivated Interferon responses and decreased TNF-α signaling. Monitoring specific dysfunctional myeloid cell subsets in peripheral blood may provide prognostic keys in COVID-19.
Identifiants
pubmed: 35783607
doi: 10.3389/fmed.2022.915367
pmc: PMC9240225
doi:
Types de publication
Case Reports
Langues
eng
Pagination
915367Subventions
Organisme : NIGMS NIH HHS
ID : R00 GM118907
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2022 Bruiners, Guerrini, Ukey, Dikdan, Yang, Mishra, Onyuka, Handler, Vieth, Carayannopoulos, Guo, Pollen, Pinter, Tyagi, Feingold, Philipp, Libutti and Gennaro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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