Robust Association Between Changes in Coronary Flow Capacity Following Percutaneous Coronary Intervention and Vessel-Oriented Outcomes and the Implication for Clinical Practice.
coronary artery disease
coronary flow capacity
coronary flow reserve
fractional flow reserve
percutaneous coronary intervention
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
03
2022
accepted:
18
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
Coronary flow capacity (CFC) is a potentially important physiologic marker of ischemia for guiding percutaneous coronary intervention (PCI) indication, while the changes through PCI have not been investigated. To assess the determinants and prognostic implication of delta CFC, defined as the change in the CFC status following PCI. From a single-center registry, a total of 450 patients with chronic coronary syndrome (CCS) who underwent fractional flow reserve (FFR)-guided PCI with pre-/post-PCI invasive coronary physiological assessments were included. Associations between PCI-related changes in thermodilution method-derived CFC categories and incident target vessel failure (TVF) were assessed. The mean ( Coronary flow capacity changes following PCI, which was largely determined by the pre-PCI CFC status, were associated with the lower risk of incident TVF in patients with CCS who underwent PCI. The CFC changes provide a mechanistic explanation on potential favorable effect of PCI on reducing vessel-oriented outcome in lesions with reduced CFC and low FFR.
Sections du résumé
Background
UNASSIGNED
Coronary flow capacity (CFC) is a potentially important physiologic marker of ischemia for guiding percutaneous coronary intervention (PCI) indication, while the changes through PCI have not been investigated.
Objectives
UNASSIGNED
To assess the determinants and prognostic implication of delta CFC, defined as the change in the CFC status following PCI.
Materials and Methods
UNASSIGNED
From a single-center registry, a total of 450 patients with chronic coronary syndrome (CCS) who underwent fractional flow reserve (FFR)-guided PCI with pre-/post-PCI invasive coronary physiological assessments were included. Associations between PCI-related changes in thermodilution method-derived CFC categories and incident target vessel failure (TVF) were assessed.
Results
UNASSIGNED
The mean (
Conclusion
UNASSIGNED
Coronary flow capacity changes following PCI, which was largely determined by the pre-PCI CFC status, were associated with the lower risk of incident TVF in patients with CCS who underwent PCI. The CFC changes provide a mechanistic explanation on potential favorable effect of PCI on reducing vessel-oriented outcome in lesions with reduced CFC and low FFR.
Identifiants
pubmed: 35783845
doi: 10.3389/fcvm.2022.901941
pmc: PMC9240228
doi:
Types de publication
Journal Article
Langues
eng
Pagination
901941Informations de copyright
Copyright © 2022 Hamaya, Yonetsu, Sayama, Matsuda, Ueno, Nagamine, Misawa, Hada, Hoshino, Sugiyama, Sasano and Kakuta.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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