Fertility Preservation and Restoration Options for Pre-Pubertal Male Cancer Patients: Current Approaches.
SSCs transplantation
cryopreservation
de novo morphogenesis, In vitro spermatogenesis
fertility
gonadotoxic cancer treatment
spermatogonial cell
testicular tissue transplantation
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
02
2022
accepted:
25
04
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
epublish
Résumé
Fertility preservation for prepubertal male patients undergoing gonadotoxic therapies, potentially depleting spermatogonial cells, is an expanding necessity, yet most of the feasible options are still in the experimental phase. We present our experience and a summary of current and novel possibilities regarding the different strategies to protect or restore fertility in young male patients, before proceeding with chemotherapy or radiotherapy for malignances or other diseases. Adult oncological patients should always be counselled to cryopreserve the semen before starting treatment, however this approach is not suitable for prepubertal boys, who aren't capable to produce sperm yet. Fortunately, since the survival rate of pediatric cancer patients has skyrocketed in the last decade and it's over 84%, safeguarding their future fertility is becoming a major concern for reproductive medicine. Surgical and medical approaches to personalize treatment or protect the gonads could be a valid first step to take. Testicular tissue autologous grafting or xenografting, and spermatogonial stem cells (SSCs) transplantation, are the main experimental options available, but spermatogenesis
Identifiants
pubmed: 35784573
doi: 10.3389/fendo.2022.877537
pmc: PMC9244702
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
877537Informations de copyright
Copyright © 2022 Eugeni, Arato, Del Sordo, Sidoni, Garolla, Ferlin, Calafiore, Brancorsini, Mancuso and Luca.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hum Reprod Open. 2020 Jun 06;2020(3):hoaa016
pubmed: 32529047
Chem Biol Interact. 2019 Nov 1;313:108834
pubmed: 31545955
J Ethnopharmacol. 2020 Sep 15;259:112922
pubmed: 32422360
J Androl. 2008 Jul-Aug;29(4):418-30
pubmed: 18326509
Hum Reprod. 2019 Mar 1;34(3):403-413
pubmed: 30753464
Nat Protoc. 2013 Nov;8(11):2098-104
pubmed: 24091557
Fertil Steril. 2014 Nov;102(5):1491-1498.e1
pubmed: 25241367
JAMA. 2009 Nov 18;302(19):2127-34
pubmed: 19920237
Cancer Res. 2001 Jan 15;61(2):706-10
pubmed: 11212272
Med Pediatr Oncol. 1999 Jul;33(1):2-8
pubmed: 10401490
Radiat Res. 1994 Jul;139(1):97-102
pubmed: 8016314
Med Pediatr Oncol. 1997 Apr;28(4):322-3
pubmed: 9078330
Int J Mol Sci. 2019 Nov 20;20(23):
pubmed: 31757040
Hum Reprod. 2011 Dec;26(12):3222-31
pubmed: 22016413
Br J Urol. 1988 Nov;62(5):449-53
pubmed: 2850071
Organogenesis. 2007 Oct;3(2):79-82
pubmed: 19279705
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11298-302
pubmed: 7972053
J Urol. 2001 Dec;166(6):2161-5
pubmed: 11696727
Methods Enzymol. 2006;419:400-26
pubmed: 17141064
Stem Cell Res. 2018 May;29:207-214
pubmed: 29730571
Nat Commun. 2011 Sep 13;2:472
pubmed: 21915114
Biol Reprod. 2003 Jun;68(6):2331-5
pubmed: 12606381
Hum Reprod. 2015 Nov;30(11):2463-75
pubmed: 26358785
Theriogenology. 2010 Mar 1;73(4):512-22
pubmed: 19962749
Ann Ital Chir. 2014 Feb 07;85(ePub):
pubmed: 24535695
Andrology. 2020 Jul;8(4):825-834
pubmed: 31539453
Stem Cells Cloning. 2018 Jul 06;11:23-38
pubmed: 30013372
Mol Hum Reprod. 2009 Sep;15(9):521-9
pubmed: 19561342
Hum Reprod. 2009 Jun;24(6):1322-9
pubmed: 19240057
Urology. 1987 May;:39-41
pubmed: 3590457
Cell Stem Cell. 2012 Nov 2;11(5):715-26
pubmed: 23122294
J Clin Oncol. 2010 Jan 10;28(2):332-9
pubmed: 19949008
Front Surg. 2014 Dec 02;1:47
pubmed: 25593971
BMJ. 2017 Feb 2;356:j495
pubmed: 28153821
Stem Cells Dev. 2018 Aug 1;27(15):1007-1020
pubmed: 29779447
J Urol. 2002 Oct;168(4 Pt 1):1406-7
pubmed: 12352404
Stem Cells Dev. 2017 Aug 1;26(15):1121-1131
pubmed: 28474535
Obstet Gynecol. 2010 Nov;116(5):1171-83
pubmed: 20966703
Pediatr Blood Cancer. 2014 Jan;61(1):53-67
pubmed: 23940101
Tissue Cell. 1998 Oct;30(5):583-8
pubmed: 9839481
J Endocrinol. 2010 May;205(2):133-45
pubmed: 20147357
N Engl J Med. 1987 Nov 19;317(21):1315-21
pubmed: 3683460
Fertil Steril. 2011 May;95(6):2123.e9-12
pubmed: 21300331
Hum Reprod Update. 2001 Jul-Aug;7(4):363-9
pubmed: 11476348
Reproduction. 2010 Feb;139(2):331-5
pubmed: 20015869
Mol Hum Reprod. 2018 May 1;24(5):271-282
pubmed: 29538744
J Control Release. 2016 Jul 28;234:79-89
pubmed: 27189137
J Clin Oncol. 1989 Jun;7(6):718-24
pubmed: 2497228
Sci Rep. 2017 Nov 13;7(1):15459
pubmed: 29133858
Horm Res. 2003;59 Suppl 1:21-3
pubmed: 12566716
J Urol. 1984 Jun;131(6):1142-4
pubmed: 6726915
Cell. 1996 Jun 28;85(7):1113-24
pubmed: 8674117
Hum Reprod Update. 2018 Mar 01;24(2):176-191
pubmed: 29281008
BJU Int. 2009 Jan;103(2):197-200
pubmed: 18990169
Cell Res. 2016 Jan;26(1):139-42
pubmed: 26369429
Front Endocrinol (Lausanne). 2021 May 20;12:694796
pubmed: 34093450
Hum Reprod. 2005 Jun;20(6):1676-87
pubmed: 15860503
Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17832-17841
pubmed: 32661178
Free Radic Res. 2002 Nov;36(11):1209-18
pubmed: 12592673
Hum Reprod. 2007 May;22(5):1384-95
pubmed: 17259225
Biol Reprod. 2003 Aug;69(2):612-6
pubmed: 12700182
Psychooncology. 2003 Mar;12(2):141-52
pubmed: 12619146
Front Physiol. 2018 Oct 09;9:1413
pubmed: 30356879
Biol Reprod. 2006 Aug;75(2):167-75
pubmed: 16571874
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16489-94
pubmed: 15520394
Andrology. 2013 Sep;1(5):731-40
pubmed: 23970452
Cancer. 1992 Dec 1;70(11):2703-12
pubmed: 1423201
Br J Radiol. 1980 Apr;53(628):271-8
pubmed: 6991051
Front Immunol. 2018 Apr 17;9:794
pubmed: 29755457
Reprod Fertil Dev. 2010;22(7):1057-65
pubmed: 20797343
Fertil Steril. 2011 Feb;95(2):787-91
pubmed: 21055744
Toxicol Appl Pharmacol. 2021 Dec 15;433:115772
pubmed: 34715073
Endocr Connect. 2018 Feb;7(2):R69-R87
pubmed: 29351905
Reproduction. 2008 Nov;136(5):543-57
pubmed: 18663014
Cancer Res. 2012 Oct 15;72(20):5174-8
pubmed: 22902414
Reproduction. 2008 Jul;136(1):85-93
pubmed: 18390693
Int J Clin Oncol. 2022 Feb;27(2):281-300
pubmed: 35022887
Cancer Treat Rev. 2010 Jun;36(4):277-85
pubmed: 20231056
Lancet Oncol. 2014 Oct;15(11):1215-23
pubmed: 25239573
J Stem Cell Res Ther. 2011 Nov 11;2(2):
pubmed: 24466499
Radiother Oncol. 1995 Jan;34(1):1-8
pubmed: 7792393
J Cancer Surviv. 2014 Sep;8(3):437-47
pubmed: 24711092
J Clin Invest. 2013 Apr;123(4):1833-43
pubmed: 23549087
J Natl Cancer Inst Monogr. 2005;(34):36-9
pubmed: 15784820
Mol Hum Reprod. 2017 Oct 1;23(10):674-684
pubmed: 28962037
Hum Reprod. 2002 Dec;17(12):3039-45
pubmed: 12456600
Best Pract Res Clin Endocrinol Metab. 2019 Feb;33(1):103-115
pubmed: 30448111
Biol Reprod. 2007 Jan;76(1):43-7
pubmed: 17005941
Int J Mol Sci. 2020 Feb 20;21(4):
pubmed: 32093393
Stem Cell Reports. 2021 Mar 9;16(3):597-609
pubmed: 33636117
J Pediatr Surg. 2002 Aug;37(8):1232-3
pubmed: 12149714
JBRA Assist Reprod. 2017 Feb 1;21(1):31-34
pubmed: 28333030
FASEB J. 2009 Jul;23(7):2076-87
pubmed: 19246485
Asian J Androl. 2002 Sep;4(3):201-7
pubmed: 12364977
Biol Reprod. 2010 Oct;83(4):533-9
pubmed: 20554921
Fertil Steril. 2016 Feb;105(2):256-66
pubmed: 26746133
Nat Commun. 2018 Jul 19;9(1):2819
pubmed: 30026551
J Exp Med. 2017 Jun 5;214(6):1631-1641
pubmed: 28461596
Hum Reprod. 2008 Nov;23(11):2402-14
pubmed: 18664476
J Androl. 1997 Jan-Feb;18(1):80-7
pubmed: 9089071
Biol Reprod. 2007 Feb;76(2):211-7
pubmed: 17065598
Nature. 2002 Aug 15;418(6899):778-81
pubmed: 12181567
Reproduction. 2014 Jul;148(1):109-17
pubmed: 24803491
Cell Res. 2017 Feb;27(2):241-252
pubmed: 28008926
J Androl. 2004 Nov-Dec;25(6):926-30
pubmed: 15477365
Hum Reprod Update. 2020 Nov 1;26(6):874-885
pubmed: 32935838
Hum Reprod. 2007 Jul;22(7):1899-906
pubmed: 17452397
Pediatr Hematol Oncol. 2007 Jul-Aug;24(5):371-7
pubmed: 17613883
Crit Rev Oncol Hematol. 2019 May;137:131-142
pubmed: 31014509
J Clin Invest. 2005 Jul;115(7):1855-61
pubmed: 15965502
Am J Pathol. 2005 Mar;166(3):773-81
pubmed: 15743789
Hum Reprod. 2010 Jul;25(7):1836-42
pubmed: 20488806
Reprod Biomed Online. 2013 Mar;26(3):286-98
pubmed: 23352099
Stem Cells. 2009 Jan;27(1):138-49
pubmed: 18927477
JAMA. 2011 Jun 15;305(23):2416-8
pubmed: 21673293
Horm Metab Res. 1990 Sep;22(9):494-8
pubmed: 1701752
Transl Androl Urol. 2014 Dec;3(4):382-90
pubmed: 26816794
Biol Reprod. 2004 May;70(5):1500-3
pubmed: 14736818
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14302-7
pubmed: 16183739
Biol Reprod. 2010 May;82(5):888-95
pubmed: 20107205
Best Pract Res Clin Endocrinol Metab. 2011 Apr;25(2):287-302
pubmed: 21397199
Cell Prolif. 2010 Aug;43(4):405-17
pubmed: 20590666
Hum Reprod. 2007 Jun;22(6):1603-11
pubmed: 17483089
Fertil Steril. 2018 Nov;110(6):1045-1057.e3
pubmed: 30396549
J Endocrinol. 1989 Jan;120(1):161-5
pubmed: 2493061
Reproduction. 2002 Sep;124(3):339-46
pubmed: 12201807
J Androl. 2008 May-Jun;29(3):312-29
pubmed: 18046051
Fertil Steril. 2020 Mar;113(3):500-509
pubmed: 32111477
Basic Clin Pharmacol Toxicol. 2017 Feb;120(2):152-158
pubmed: 27649639
J Androl. 1994 Nov-Dec;15(6):608-13
pubmed: 7721664
Hum Reprod. 2013 Apr;28(4):897-907
pubmed: 23427228
Hum Reprod. 2011 Feb;26(2):282-93
pubmed: 21123192
Cell Res. 2018 Dec;28(12):1141-1157
pubmed: 30315278
Hum Reprod. 1999 Jan;14(1):144-50
pubmed: 10374111
Nat Commun. 2014 Jul 01;5:4320
pubmed: 24984101
Ann Intern Med. 1997 Feb 15;126(4):292-5
pubmed: 9036801
Hum Reprod. 2007 Mar;22(3):733-42
pubmed: 17082221
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
J Vis Exp. 2019 Oct 3;(152):
pubmed: 31633676
Theriogenology. 2016 Jan 15;85(2):193-9
pubmed: 26474686
Transl Androl Urol. 2019 Oct;8(5):540-547
pubmed: 31807430
BMJ. 1999 Oct 9;319(7215):935-6
pubmed: 10514140
Methods Mol Biol. 2019;1576:283-290
pubmed: 28674937
Endocrinology. 2008 Apr;149(4):1736-47
pubmed: 18174281
Radiat Res. 1974 Sep;59(3):665-78
pubmed: 4428015
Front Physiol. 2019 Sep 19;10:1155
pubmed: 31607938
Reproduction. 2006 Jun;131(6):1091-8
pubmed: 16735548
Eur J Cancer. 2009 Mar;45(5):814-8
pubmed: 19216070
Hum Reprod. 2013 Mar;28(3):578-89
pubmed: 23315062
Fertil Steril. 2008 Nov;90(5):2019-22
pubmed: 18439593
Horm Res. 2003;59 Suppl 1:12-20
pubmed: 12566715
Fertil Steril. 2014 Apr;101(4):1072-1078.e1
pubmed: 24581582
Biol Reprod. 2004 Aug;71(2):494-501
pubmed: 15070832
Stem Cell Reports. 2014 Oct 14;3(4):663-75
pubmed: 25358793
Fertil Steril. 2009 May;91(5 Suppl):2264-72
pubmed: 18394623
Exp Cell Res. 1964 Oct;36:19-27
pubmed: 14222741
Lancet. 1999 Feb 13;353(9152):555-6
pubmed: 10028987
Reproduction. 2009 Oct;138(4):667-77
pubmed: 19633133
Andrology. 2021 Sep;9(5):1603-1616
pubmed: 33960147
J Androl. 2006 Jul-Aug;27(4):611-8
pubmed: 16582408
Eur J Obstet Gynecol Reprod Biol. 2019 Feb;233:84-92
pubmed: 30580229
Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):85-96
pubmed: 21410649
Exp Biol Med (Maywood). 2004 Nov;229(10):988-95
pubmed: 15522834
Cancer Chemother Pharmacol. 1987;19(2):159-62
pubmed: 3105906
J Oncol Pract. 2018 Jun;14(6):381-385
pubmed: 29768110
Biomater Sci. 2021 May 4;9(9):3465-3484
pubmed: 33949391
Biol Reprod. 2006 Feb;74(2):314-21
pubmed: 16237148
Hum Reprod. 2018 Dec 1;33(12):2249-2255
pubmed: 30358843
Biol Reprod. 2003 Oct;69(4):1260-4
pubmed: 12801978
Fertil Steril. 2012 Dec;98(6):1443-8.e1
pubmed: 22981175
Int J Mol Sci. 2021 May 28;22(11):
pubmed: 34071329
Science. 2019 Mar 22;363(6433):1314-1319
pubmed: 30898927
Biol Reprod. 2010 Feb;82(2):363-72
pubmed: 19846602
Mol Reprod Dev. 1999 Jun;53(2):142-8
pubmed: 10331452
Hum Reprod. 2006 Feb;21(2):484-91
pubmed: 16210383
Xenotransplantation. 2015 Jul-Aug;22(4):273-83
pubmed: 26134468
Reprod Biomed Online. 2019 Jul;39(1):119-133
pubmed: 31005581
Biol Reprod. 2009 Nov;81(5):898-905
pubmed: 19571259
Lancet Oncol. 2017 Feb;18(2):e75-e90
pubmed: 28214419
Reprod Biomed Online. 2017 Mar;34(3):291-297
pubmed: 28040413
Hum Reprod. 2009 Jun;24(6):1480-91
pubmed: 19246463
Hum Reprod. 2014 Nov;29(11):2497-511
pubmed: 25267789
BJU Int. 2012 Oct;110(8):1102-9
pubmed: 22429248
Lancet. 1981 Sep 26;2(8248):657-8
pubmed: 6116044
Tissue Cell. 2001 Apr;33(2):200-7
pubmed: 11392673
J Reprod Dev. 2018 Jun 22;64(3):267-275
pubmed: 29657241
J Vis Exp. 2020 Oct 7;(164):
pubmed: 33104061
Hum Reprod. 2019 Jun 4;34(6):966-977
pubmed: 31111889
Eur Urol. 1993;23(1):148-51; discussion 152
pubmed: 8386642
Transl Res. 2014 Apr;163(4):268-85
pubmed: 24291155
Hum Reprod. 2009 Sep;24(9):2255-63
pubmed: 19525299
Endocr Relat Cancer. 2004 Dec;11(4):589-602
pubmed: 15613441
Cancer. 2011 May 15;117(10 Suppl):2301-10
pubmed: 21523750
J Androl. 2004 Jul-Aug;25(4):586-92
pubmed: 15223847
Br J Cancer. 2005 Jul 25;93(2):200-7
pubmed: 15999104
Development. 2009 Apr;136(7):1191-9
pubmed: 19270176
Arch Dis Child. 2006 Aug;91(8):715-6
pubmed: 16861494
Cancer. 1982 Jul 15;50(2):337-40
pubmed: 7083140
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17430-5
pubmed: 16293688
Biol Reprod. 2014 Oct;91(4):92
pubmed: 25165119
Science. 2000 Feb 25;287(5457):1489-93
pubmed: 10688798
Fertil Steril. 2013 Oct;100(4):981-8
pubmed: 23850302
Dev Cell. 2020 Aug 24;54(4):529-547.e12
pubmed: 32504559