Pharmacogenetics: A Precision Medicine Approach to Combatting the Opioid Epidemic.
CYP
Opioids
Personalized Medicine
Pharmacogenetics
precision medicine
tramadol
Journal
Journal of the American College of Clinical Pharmacy : JACCP
ISSN: 2574-9870
Titre abrégé: J Am Coll Clin Pharm
Pays: United States
ID NLM: 101723133
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
ppublish
Résumé
Ineffective pain control is the most commonly cited reason for misuse of prescription opioids and is influenced by genetics. In particular, the gene encoding the CYP2D6 enzyme, which metabolizes some of the most commonly prescribed opioids (e.g., tramadol, hydrocodone) to their more potent forms, is highly polymorphic and can lead to reduced concentrations of the active metabolites and decreased opioid effectiveness. Consideration of the
Identifiants
pubmed: 35784584
doi: 10.1002/jac5.1582
pmc: PMC9248444
mid: NIHMS1765712
doi:
Types de publication
Journal Article
Langues
eng
Pagination
239-250Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG007269
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest: DM Smith reports grants (to institution) from Kailos Genetics
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