Modeling of SGLT1 in Reconstituted Systems Reveals Apparent Ion-Dependencies of Glucose Uptake and Strengthens the Notion of Water-Permeable Apo States.
glucose uptake
human sodium glucose co-transporter
lipid vesicles
mathematical modeling
passive membrane permeabilities
solute carrier
water-permeable apo states
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
02
2022
accepted:
10
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions to fuel concentrative uptake of their cognate substrate. In liposomal preparations, these gradients can be set by the experimenter. However, due to passive diffusion of the ions and solutes through the membrane, the gradients are not stable and little is known on the time course by which they dissipate and how the presence of a transporter affects this process. Gradient dissipation can also generate a transmembrane potential (V
Identifiants
pubmed: 35784872
doi: 10.3389/fphys.2022.874472
pii: 874472
pmc: PMC9242095
doi:
Types de publication
Journal Article
Langues
eng
Pagination
874472Informations de copyright
Copyright © 2022 Barta, Sandtner, Wachlmayr, Hannesschlaeger, Ebert, Speletz and Horner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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